CAJ | 학술논문

顺式调控假说是当前进化发育生物学中重要的理论之一，该假说认为顺式调控元件的进化是调控外表性状进化的主要遗传机制。然而越来越多的实验结果表明，仅靠顺式调控假说远不足以解释复杂的进化发育过程，其他因素也会导致表型的进化，如：与顺式调控元件相联基因的蛋白序列改变；基因及染色体组复制；蛋白结构域与顺式调控元件的灵活性等。文章回顾了近年来顺式调控元件以及与顺式调控元件相联基因的进化发育研究，探讨了进化发育生物学研究的新方法与新思路。
순식조공가설시당전진화발육생물학중중요적이론지일，해가설인위순식조공원건적진화시조공외표성상진화적주요유전궤제。연이월래월다적실험결과표명，부고순식조공가설원불족이해석복잡적진화발육과정，기타인소야회도치표형적진화，여：여순식조공원건상련기인적단백서렬개변；기인급염색체조복제；단백결구역여순식조공원건적령활성등。문장회고료근년래순식조공원건이급여순식조공원건상련기인적진화발육연구，탐토료진화발육생물학연구적신방법여신사로。
Cis-regulatory hypothesis is one of the most important theories in evolutionary developmental biology (evo-devo), which claims that evolution of cis-regulatory elements (CREs) plays a key role during evolution of morphology. However, an increasing number of experimental results show that cis-regulatory hypothesis alone is not far enough to ex-plain the complexity of evo-devo processes. Other modifications, including mutations of protein coding, gene and genome duplications, and flexibility of homeodomains and CREs, also cause the morphological changes in animals. In this review, we retrospect the recent results of evolution of CREs and genes associated with CREs and discuss new methods and trends for research in evo-devo.