CAJ | 학술논문

1型糖尿病是一种由于自体免疫细胞破坏分泌胰岛素的β细胞而引起胰岛素绝对缺乏的自体免疫病。疾病患者需要依靠外源性途径来补给胰岛素，但胰岛素注射治疗不能根治病症，也不能有效地预防糖尿病并发症。多能性干细胞以及体细胞重编程产生胰岛素分泌细胞为根治1型糖尿病提供了可能。编程性的细胞能被用来进行移植治疗和药物筛选，为1型糖尿病的治疗带来了新的希望。当前，通过相关转录调节因子重编程终末分化细胞为胰岛β细胞已经取得了很大进展。文章对胰腺早期发育、胰腺相关转录调控因子及目前利用终末分化细胞重编程产生胰岛β细胞的研究内容进行了综述。
1형당뇨병시일충유우자체면역세포파배분비이도소적β세포이인기이도소절대결핍적자체면역병。질병환자수요의고외원성도경래보급이도소，단이도소주사치료불능근치병증，야불능유효지예방당뇨병병발증。다능성간세포이급체세포중편정산생이도소분비세포위근치1형당뇨병제공료가능。편정성적세포능피용래진행이식치료화약물사선，위1형당뇨병적치료대래료신적희망。당전，통과상관전록조절인자중편정종말분화세포위이도β세포이경취득료흔대진전。문장대이선조기발육、이선상관전록조공인자급목전이용종말분화세포중편정산생이도β세포적연구내용진행료종술。
Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which the immune system attacks insu-lin-secretingβcells, thus leading to an absolute deficiency of insulin. Patients must rely on exogenous insulin, which cannot effectively prevent diabetes complications. Generation of insulin-secreting cells by reprogramming of pluripotent stem cells or somatic cells is a potential approach for the treatment of T1DM. These cells can be used for cell therapy and drug screening, and may eventually provide a cure for the disease. Significant progress has been made in generating insu-lin-secreting cells through the expression ofβcell specific transcription factors in stem cells or somatic cells. In this review, we summarize recent research progress in early pancreas development,βcell specific transcription factors and reprogram-ming of terminally differentiated cells intoβcells.