CAJ | 학술논문

目的：探讨湖北黄石地区氯吡格雷治疗患者 CYP2C19不同代谢表型的分布。方法取76例心内科住院氯吡格雷治疗患者的外周血，采用基因芯片方法对 CYP2C19基因进行分型，了解其代谢表型的分布，并与文献报道的中国正常汉族人群进行比较。结果在76例检测标本中检测出 CYP2C19的3种代谢表型，快代谢型、中间代谢型以及慢代谢型，所占比例分别为39．47％、44．74％和15．79％。与中国健康汉族人总体比例基本一致。结论湖北黄石地区氯吡格雷治疗患者的临床个体化用药方案可以中国汉族健康人群的个体化用药方案为参考依据。
목적：탐토호북황석지구록필격뢰치료환자 CYP2C19불동대사표형적분포。방법취76례심내과주원록필격뢰치료환자적외주혈，채용기인심편방법대 CYP2C19기인진행분형，료해기대사표형적분포，병여문헌보도적중국정상한족인군진행비교。결과재76례검측표본중검측출 CYP2C19적3충대사표형，쾌대사형、중간대사형이급만대사형，소점비례분별위39．47％、44．74％화15．79％。여중국건강한족인총체비례기본일치。결론호북황석지구록필격뢰치료환자적림상개체화용약방안가이중국한족건강인군적개체화용약방안위삼고의거。
Objective To investigate the distribution of CYP2C19 metabolism phenotype in patients with clopidogrel treatment in Huangshi.Methods The peripheral blood samples were obtained from 76 patients with clopidogrel treatment in Cardiovascular Department.CYP2C19 genotypes were determined by the gene chip,CYP2C19 metabolism phenotype were investigated and com-pared with the data of healthy Han Chinese from the published papers.Results There were three kinds of metabolizers about the metabolism phenotypes of CYP2C19,which were extensive metabolizers,intermediate metabolizers and poor metabolizers.In the 76 patients,the ratios of these metabolism phenotypes were 39.47%,44.74% and 15.79%,respectively.The result coincided with the healthy Han Chinese.Conclusion The clinical individualized medication of healthy Han Chinese could be refered to the clinical indi-vidualized medication of patients with clopidogrel treatment in Huangshi.