CAJ | 학술논문

目的：探讨甲状腺激素水平在稳定型冠心病合并不同糖代谢状态的患者中的意义。方法采用电化学发光法检测173例稳定型冠心病合并不同糖代谢状态的患者和58例健康对照者血中甲状腺激素水平，所有研究者均行75 g 葡萄糖粉口服试验评价糖代谢情况和胰岛素抵抗指数。结果甲状腺激素、收缩压、舒张压和胰岛素抵抗指数在稳定型冠心病合并不同糖代谢状态患者中的差异均无统计学意义（P ＞0．05）。稳定型冠心病合并2型糖尿病组患者的空腹血糖、餐后2 h 血糖和糖化血红蛋白高于稳定型冠心病合并糖耐量减退和正常糖耐量组，差异均有统计学意义（P ＜0．05）。稳定型冠心病合并糖耐量减退组患者的餐后2 h 血糖高于稳定型冠心病合并正常糖耐量组和健康对照组，差异均有统计学意义（P ＜0．05）。结论血清甲状腺激素水平可能不是参与冠心病合并糖尿病发病机制的影响因素。
목적：탐토갑상선격소수평재은정형관심병합병불동당대사상태적환자중적의의。방법채용전화학발광법검측173례은정형관심병합병불동당대사상태적환자화58례건강대조자혈중갑상선격소수평，소유연구자균행75 g 포도당분구복시험평개당대사정황화이도소저항지수。결과갑상선격소、수축압、서장압화이도소저항지수재은정형관심병합병불동당대사상태환자중적차이균무통계학의의（P ＞0．05）。은정형관심병합병2형당뇨병조환자적공복혈당、찬후2 h 혈당화당화혈홍단백고우은정형관심병합병당내량감퇴화정상당내량조，차이균유통계학의의（P ＜0．05）。은정형관심병합병당내량감퇴조환자적찬후2 h 혈당고우은정형관심병합병정상당내량조화건강대조조，차이균유통계학의의（P ＜0．05）。결론혈청갑상선격소수평가능불시삼여관심병합병당뇨병발병궤제적영향인소。
Objective To evaluate the importance of serum thyroid hormonens level of patients with stable coronary heart disease(CAD)in different glucose metablic statuses.Methods 173 cases of CAD patients in different glucose metablic statuses and 58 cases of healthy people were enrolled in the study.The levels of thyroid hormonens and serum insulin was measured by electro-chemiluminescence,and the evaluation of glucose metablic statuses and insulin resistance index was by means of 75 g oral glucose tolerance test.Results There was no significant difference in the levels of systolic pressure(SBP),diastolic pressure(DBP),insulin resistence index and serum thyroid hormonens among CAD patients with different glucose metablic statuses(P >0.05).The levels of fasting plasma glucose,2 hour postprandial plasma glucose(PG2h)and glycosylated hemoglobin(HbA1c)in CAD complicated with type 2 diabetes group were significantly higher than those in CAD complicated with impaired glucose tolerance group and CAD complicated with normal glucose tolerance group (P < 0.05 ).And the PG2h level of CAD complicated with impaired glucose tolerance group was significantly higher than both of CAD complicated with normal glucose tolerance group and normal control group s(P <0.05).Conclusion It indicates that serum thyroid hormonens level may not affect glycometabolism in CAD patients.