CAJ | 학술논문

目的：研究Vimentin在宫颈癌组织中的表达与淋巴转移及宫旁浸润的关系，以探讨Vimentin预测宫颈癌淋巴转移及宫旁浸润的可能性．方法免疫组化法检测宫颈癌组织微阵列芯片78例组织标本Vimentin表达，数据用SPSS软件进行统计分析处理，＜0.05为差异有统计学意义．结果（1）78例宫颈癌组织中Vimentin阳性表达率为30/78（38.5%），Vimentin在宫颈癌组织中表达与淋巴转移和宫旁浸润相关，淋巴转移组Vimentin表达率为15/31（48.4%），显著高于淋巴转移阴性组的15/47（31.9%）；（2）宫旁浸润组Vimentin表达率为17/32（53.1%），显著高于宫旁无浸润组15/46（32.6%）的表达率（＜0.05）．结论 Vimentin在宫颈癌组织中的表达与淋巴转移及宫旁浸润之间存在相关性，检测宫颈癌组织Vimentin可有效预测宫颈癌淋巴转移及宫旁浸润．
목적：연구Vimentin재궁경암조직중적표체여림파전이급궁방침윤적관계，이탐토Vimentin예측궁경암림파전이급궁방침윤적가능성．방법면역조화법검측궁경암조직미진렬심편78례조직표본Vimentin표체，수거용SPSS연건진행통계분석처리，＜0.05위차이유통계학의의．결과（1）78례궁경암조직중Vimentin양성표체솔위30/78（38.5%），Vimentin재궁경암조직중표체여림파전이화궁방침윤상관，림파전이조Vimentin표체솔위15/31（48.4%），현저고우림파전이음성조적15/47（31.9%）；（2）궁방침윤조Vimentin표체솔위17/32（53.1%），현저고우궁방무침윤조15/46（32.6%）적표체솔（＜0.05）．결론 Vimentin재궁경암조직중적표체여림파전이급궁방침윤지간존재상관성，검측궁경암조직Vimentin가유효예측궁경암림파전이급궁방침윤．
Objective To investigate the relationship between the Vimentin expression and lymph node metastasis of cervical cancer in order to explore the possibility of its predictive value on the lymph node metastasis and parametrial infiltration. Methods The expression of Vimentin in cervical cancer tissue microarray chip which contains 78 cases was evaluated by immunohistochemistry method to study the relationship between the expression and lymph node metastasis and parametrial infiltration of cervical cancer. Results The expression of vimentin in 78 cases of cervical cancer tissue was 30/78 (38.5%) .The expression of vimentin in cervical cancer was significantly related to lymph node metastasis and parametrial infiltration respectively. The expression of Vimentin in lymph node metastasis positive group was 15/31 (48.4%), which were significantly higher than that in lymph node metastasis negative group. The expression of Vimentin in parametrial infiltration positive group was 17/32 (53.1%), which were significantly higher than that in parametrial infiltration negative group ( <0.05) . Conclusions The expression of vimentin in cervical cancer tissue is correlated with lymph node metastasis and parametrial infiltration. It is an effective way to predict the lymph node metastasis and parametrial infiltration in cervical cancer patients.