CAJ | 학술논문

糖皮质激素（glucocorticoid．GC）在临床应用广泛，其主要的副作用之一是对骨的影响，导致糖皮质激素性骨质疏松(glucocorticoid induced osteoporosis．GIOP)的风险显著增加。目前研究认为其机制为：糖皮质激素通过调高细胞外因子DKK1、SFRPs的表达水平抑制Wnt/β-catenin信号通路，从而抑制骨细胞形成；通过增强成骨负性因子SOST、PPARγ2的活性，弱化成骨活性因子Cbfal、IGF-1的表达来抑制骨形成。同时通过调节OPG/RANKL/RANK途径促进骨吸收。本文从糖皮质激素对骨形成和骨吸收两个方面的影响对糖皮质激素性骨质疏松的发生机制进行探讨，综述了近几年国内外对糖皮质激素性骨质疏松的研究现状，以此为该疾病的治疗提供相关理论帮助。
당피질격소（glucocorticoid．GC）재림상응용엄범，기주요적부작용지일시대골적영향，도치당피질격소성골질소송(glucocorticoid induced osteoporosis．GIOP)적풍험현저증가。목전연구인위기궤제위：당피질격소통과조고세포외인자DKK1、SFRPs적표체수평억제Wnt/β-catenin신호통로，종이억제골세포형성；통과증강성골부성인자SOST、PPARγ2적활성，약화성골활성인자Cbfal、IGF-1적표체래억제골형성。동시통과조절OPG/RANKL/RANK도경촉진골흡수。본문종당피질격소대골형성화골흡수량개방면적영향대당피질격소성골질소송적발생궤제진행탐토，종술료근궤년국내외대당피질격소성골질소송적연구현상，이차위해질병적치료제공상관이론방조。
Glucocorticoids (glucocorticoid.GC) are widely used in clinic, one of the main side effects are effects on bone, glucocor-ticoid induced osteoporosis (glucocorticoid induced osteoporosis.GIOP) significantly increased the risk of. Glucocorticoid inhibition of Wnt/ β -catenin pathway through the adjustable high expression levels of cytokines DKK1, SFRPs, thereby inhibiting bone for-mation by enhancing cell; Osteogenic negative factor SOST, PPAR γ 2 activity, weakening the expression of osteogenic activity of factor Cbfal, IGF-1 to inhibit bone formation. At the same time, by regulating the OPG/RANKL/RANK pathway promotes bone re-sorption. This article carries on the discussion from the GC formation and bone resorption on two aspects of the mechanism of GIOP on bon,which is to provide the theoretical help for the treatment of diseases.