CAJ | 학술논문

急性肺栓塞%全球急性冠状动脉事件注册( GRACE)评分%Geneva预后评分%简化急性肺栓塞严重程度指数(sPESI)%欧洲心脏病学会(ESC)评分%病死率急性肺栓塞%全毬急性冠狀動脈事件註冊( GRACE)評分%Geneva預後評分%簡化急性肺栓塞嚴重程度指數(sPESI)%歐洲心髒病學會(ESC)評分%病死率
급성폐전새%전구급성관상동맥사건주책( GRACE)평분%Geneva예후평분%간화급성폐전새엄중정도지수(sPESI)%구주심장병학회(ESC)평분%병사솔
Acute pulmonary embolism%Global Registry of Acute Coronary Events ( GRACE) score%Geneva score%Simplified pulmonary embolism severity index (sPESI)%European Society of Cardiology (ESC) risk scores%Mortality

目的：探讨全球急性冠状动脉事件注册（ GRACE）评分预测急性肺栓塞患者临床转归的适用性。方法对103例连续性急性肺栓塞住院患者进行了GRACE评分、Geneva预后评分、简化急性肺栓塞严重程度指数和欧洲心脏病学会评分检测，并对上述预后评分方法预测主要终点（30 d全因病死率）的效能进行了分析和比较。预测效能的评估指标为受试者工作特征曲线下面积（AUC）。结果纳入此研究患者的30 d全因病死率为18．4％。依据GRACE评分分类为低危组的患者均未发生不良事件（ GRACE 评分≤109的阴性预测值为100％）。 GRACE 评分（AUC 0．715，95％CI 0．63～0．80）比Geneva预后评分（AUC 0．623，95％CI 0．53～0．71）、欧洲心脏病学会评分（AUC 0．662，95％CI 0．57～0．76）及简化急性肺栓塞严重程度指数（AUC 0．705，95％CI 0．61～0．80）具有更高的预测效能。结论 GRACE评分有预测急性肺栓塞患者30 d病死率的价值。
목적：탐토전구급성관상동맥사건주책（ GRACE）평분예측급성폐전새환자림상전귀적괄용성。방법대103례련속성급성폐전새주원환자진행료GRACE평분、Geneva예후평분、간화급성폐전새엄중정도지수화구주심장병학회평분검측，병대상술예후평분방법예측주요종점（30 d전인병사솔）적효능진행료분석화비교。예측효능적평고지표위수시자공작특정곡선하면적（AUC）。결과납입차연구환자적30 d전인병사솔위18．4％。의거GRACE평분분류위저위조적환자균미발생불량사건（ GRACE 평분≤109적음성예측치위100％）。 GRACE 평분（AUC 0．715，95％CI 0．63～0．80）비Geneva예후평분（AUC 0．623，95％CI 0．53～0．71）、구주심장병학회평분（AUC 0．662，95％CI 0．57～0．76）급간화급성폐전새엄중정도지수（AUC 0．705，95％CI 0．61～0．80）구유경고적예측효능。결론 GRACE평분유예측급성폐전새환자30 d병사솔적개치。
Objective To explore the applicability and extend the use of the Global Registry of Acute Coronary Events ( GRACE) risk score to acute pulmonary embolism ( PE) .Methods A case-control study of 103 consecutive patients admitted with acute PE was performed .The GRACE risk score , Geneva score , simplified Pulmonary Embolism Severity Index , and European Society of Cardiology risk scores were tested for the prediction of the primary end point: all -cause 30 -day mortality. Comparisons between GRACE and the other risk scores were performed using receiver operating characteristic area under the curve .Results All-cause 30-day mortality was observed in 18 .4% of the patients.Unlike the other classifications , no adverse outcomes were observed in patients classified as low risk using the GRACE risk score (100%negative predictive value for GRACE risk score ≤109). The GRACE score showed greater discriminative performance than the Geneva score ( area under the curve 0.623, 95%CI 0.53 to 0.71), European Society of Cardiology (area under the curve 0.662, 95%CI 0.57 to 0.76), and simplified Pulmonary Embolism Severity Index ( area under the curve 0.705, 95%CI 0.61 to 0.80).Conclusion Our results have demonstrated that the GRACE risk score can accurately predict 30-day mortality in patients admitted for acute PE .