CAJ | 학술논문

目的：探讨结核感染对小儿支气管哮喘吸入糖皮质激素治疗长期效果的影响。方法：按有无结核感染将70例小儿支气管哮喘患儿分为观察组和对照组（各35例），所有患者均使用糖皮质激素治疗，观察组进行抗结核治疗，比较相关指标间的差异。结果：经过治疗，观察组患者肺功能改善情况优于对照组，Th1/Th2的比例和白细胞介素27随着ICS治疗时间的延长而上升，但观察组较对照组高，其差异皆有统计学意义。结论：结核感染可能通过IL-27水平的变化影响体内T细胞亚群的分布，进而对小儿支气管哮喘ICS治疗发挥积极作用。
목적：탐토결핵감염대소인지기관효천흡입당피질격소치료장기효과적영향。방법：안유무결핵감염장70례소인지기관효천환인분위관찰조화대조조（각35례），소유환자균사용당피질격소치료，관찰조진행항결핵치료，비교상관지표간적차이。결과：경과치료，관찰조환자폐공능개선정황우우대조조，Th1/Th2적비례화백세포개소27수착ICS치료시간적연장이상승，단관찰조교대조조고，기차이개유통계학의의。결론：결핵감염가능통과IL-27수평적변화영향체내T세포아군적분포，진이대소인지기관효천ICS치료발휘적겁작용。
Objective:To investigate the effect and mechanism of tuberculosis ( TB ) infection in the treatment of bronchial asthma with inhaled corticosteroids ( ICS ) in children .Method: 70 children with bronchial asthma were divided into observing group (35cases with TB) and control group (35 cases without TB) .ICS treatments were put in all the patients and the anti-tuberculosis treatment was used in observing group patients only.The results of lung function and the related indices of immunology were compared be-tween two groups.Result:There was significant difference in the comparison of lung function.The related lung function indexes of observing group were higher than the control group.The Th1/Th2 and interleukin 27 rising as ICS increased with the extension of treatment time.Conclusion:The TB infection can play a posi-tive role in the ICS treatment for children with bronchial asthma , as it maybe have a positive influence to the distribution of T cell subgroup through the impact of IL -27 which would rise in the TB infection .