CAJ | 학술논문

目的：探讨湘西地区侗族人群2型糖尿病(type 2 diabetes mellitus，T2DM)的相关危险因素，为该地区T2DM的防治提供科学依据。方法：采用病例对照研究方法，通过口服葡萄糖耐量试验(oral glucose tolerance test，OGTT)将研究对象分为T2DM，糖调节受损(impaired glucose regulation，IGR)和糖耐量正常(normal glucose tolerance，NGT)3组，分别对3组人群进行问卷调查、体格测量以及血糖、血脂、血清胰岛素等生化指标检测。结果：单因素分析结果发现：不同糖代谢组间的年龄，空腹胰岛素(fasting insulin，FINS)， HOMA模型胰岛素抵抗指数(HOMA insulin resistance index，HOMA-IRI)和β细胞功能指数(HOMA β-cell function index，HOMA-βC)，三酰甘油(trigalloyl glycerol，TG)，高密度脂蛋白胆固醇(high density lipoprotein cholesferol，HDL-C)，收缩压，舒张压等指标差异有统计学意义(P<0.05)；体质量指数(body mass index，BMI)、腰臀比(waist/hip ratio，WHR)、糖尿病家族史、每周体力活动次数、吃饭口味、高脂高蛋白食物、新鲜蔬菜和水果摄入量与糖尿病有关。多因素非条件ordinal logistic回归分析发现：年龄是糖尿病的危险因素，与年龄≤50岁组相比，50岁<年龄≤60岁组，60岁<年龄≤70岁组和年龄>70岁组的OR值分别是1.85，2.83和2.64(P<0.05)；BMI为超重或肥胖人群患糖尿病的风险是BMI正常人群的2.13倍(P<0.01)；其他影响因素包括WHR(OR=2.06)，糖尿病家族史(OR=11.36)，高脂高蛋白食物(OR=1.90)。结论：湘西地区侗族人群T2DM的影响因素主要有年龄、BMI、WHR、糖尿病家族史、高脂高蛋白食物，提示今后应加强湘西地区侗族人群T2DM的健康教育，降低患T2DM的风险。
목적：탐토상서지구동족인군2형당뇨병(type 2 diabetes mellitus，T2DM)적상관위험인소，위해지구T2DM적방치제공과학의거。방법：채용병례대조연구방법，통과구복포도당내량시험(oral glucose tolerance test，OGTT)장연구대상분위T2DM，당조절수손(impaired glucose regulation，IGR)화당내량정상(normal glucose tolerance，NGT)3조，분별대3조인군진행문권조사、체격측량이급혈당、혈지、혈청이도소등생화지표검측。결과：단인소분석결과발현：불동당대사조간적년령，공복이도소(fasting insulin，FINS)， HOMA모형이도소저항지수(HOMA insulin resistance index，HOMA-IRI)화β세포공능지수(HOMA β-cell function index，HOMA-βC)，삼선감유(trigalloyl glycerol，TG)，고밀도지단백담고순(high density lipoprotein cholesferol，HDL-C)，수축압，서장압등지표차이유통계학의의(P<0.05)；체질량지수(body mass index，BMI)、요둔비(waist/hip ratio，WHR)、당뇨병가족사、매주체력활동차수、흘반구미、고지고단백식물、신선소채화수과섭입량여당뇨병유관。다인소비조건ordinal logistic회귀분석발현：년령시당뇨병적위험인소，여년령≤50세조상비，50세<년령≤60세조，60세<년령≤70세조화년령>70세조적OR치분별시1.85，2.83화2.64(P<0.05)；BMI위초중혹비반인군환당뇨병적풍험시BMI정상인군적2.13배(P<0.01)；기타영향인소포괄WHR(OR=2.06)，당뇨병가족사(OR=11.36)，고지고단백식물(OR=1.90)。결론：상서지구동족인군T2DM적영향인소주요유년령、BMI、WHR、당뇨병가족사、고지고단백식물，제시금후응가강상서지구동족인군T2DM적건강교육，강저환T2DM적풍험。
Objective: To explore the risk factors oftype 2 diabetes mellitus (T2DM) of Dong nationality in Western Hunan, and to provide a scientific basis for the prevention and treatment of T2DM in the district. <br> Methods: In the case-control study, the subjects were divided into a T2DM group, an impaired glucose regulation (IGR) group and a normal glucose tolerance (NGT) group through oral glucose tolerance test (OGTT). A questionnaire survey was conducted, and physical measurements and the detection of blood glucose, blood lipids and serum insulin were done. <br> Results: Univariate analysis found signiifcant difference in age, fasting insulin (FINS), HOMA insulin resistance index (HOMA-IRI), HOMA β-cell function index (HOMA-βC), trigalloyl glycerol (TG), high density lipoprotein cholesterol (HDL-C), systolic blood pressure, and diastolic blood pressure in the glucose metabolism among different groups (P<0.05). Body mass index (BMI), waist/hip ratio (WHR), family history of diabetes, number of physical activities per week, dinner taste, fat and protein-rich foods, fresh vegetables and fruits intake were associated with T2DM.Multifactor non-conditional ordinal logistic regression indicated that age was the risk factor of T2DM and IGR. Compared with the group whose age was≤50, the odds ratios of the groups of 50<age≤60, 60<age≤70 and age>70 were 1.85, 2.83 and 2.64 respectively,P<0.05. The risk of suffering from diabetes of the overweighted or obese people was 2.13 times that of a normal BMI group,P<0.01. The other inlfuencing factors included WHR (OR=2.06), family history of diabetes (OR=11.36), and fat and protein-rich foods (OR=1.90). <br> Conclusion: The main influencing factors of T2DM of Dong nationality in Western Hunan include age, BMI, WHR, family history of diabetes, fat and protein-rich foods. We must strengthen the health eduation of T2DM of Dong nationality in Western Hunan to reduce the risk of T2DM.