中国药物应用与监测
中國藥物應用與鑑測
중국약물응용여감측
CHINESE JOURNAL OF DRUG APPLICATION AND MONITORING
2013年
5期
300-301
,共2页
左氧氟沙星%血压升高%药品不良反应
左氧氟沙星%血壓升高%藥品不良反應
좌양불사성%혈압승고%약품불량반응
Levolfoxacin%Elevated blood pressure%Adverse drug reaction
1例75岁女性患者，因细菌性肺炎、肺部阴影待查入院。给予乳酸左氧氟沙星氯化钠注射液600 mg，ivgtt，qd，输液速度1.5 mL· min-1，输液结束后，患者突然头痛、胸闷、恶心、呕吐。T 38.6℃，BP 160/80 mm Hg，神志清晰，R 20次· min-1， HR 82次· min-1，律齐。给予卡托普利片（12.5 mg，舌下含服）及硝苯地平缓释片（10 mg，qd）降压治疗，血压稍微下降，但次日再度升高。停用左氧氟沙星，换头孢米诺钠抗感染治疗，血压逐渐恢复正常。因患者抗感染效果欠佳，再次给予左氧氟沙星氯化钠注射液300 mg，ivgtt，qd，同时给予硝苯地平缓释片10 mg，bid，并监测血压，7 d后患者血压再度升高，增加降压药用量继续使用左氧氟沙星6 d，患者血压一直在高位波动。停用左氧氟沙星3 d后患者血压恢复正常，未再出现血压增高。
1例75歲女性患者，因細菌性肺炎、肺部陰影待查入院。給予乳痠左氧氟沙星氯化鈉註射液600 mg，ivgtt，qd，輸液速度1.5 mL· min-1，輸液結束後，患者突然頭痛、胸悶、噁心、嘔吐。T 38.6℃，BP 160/80 mm Hg，神誌清晰，R 20次· min-1， HR 82次· min-1，律齊。給予卡託普利片（12.5 mg，舌下含服）及硝苯地平緩釋片（10 mg，qd）降壓治療，血壓稍微下降，但次日再度升高。停用左氧氟沙星，換頭孢米諾鈉抗感染治療，血壓逐漸恢複正常。因患者抗感染效果欠佳，再次給予左氧氟沙星氯化鈉註射液300 mg，ivgtt，qd，同時給予硝苯地平緩釋片10 mg，bid，併鑑測血壓，7 d後患者血壓再度升高，增加降壓藥用量繼續使用左氧氟沙星6 d，患者血壓一直在高位波動。停用左氧氟沙星3 d後患者血壓恢複正常，未再齣現血壓增高。
1례75세녀성환자，인세균성폐염、폐부음영대사입원。급여유산좌양불사성록화납주사액600 mg，ivgtt，qd，수액속도1.5 mL· min-1，수액결속후，환자돌연두통、흉민、악심、구토。T 38.6℃，BP 160/80 mm Hg，신지청석，R 20차· min-1， HR 82차· min-1，률제。급여잡탁보리편（12.5 mg，설하함복）급초분지평완석편（10 mg，qd）강압치료，혈압초미하강，단차일재도승고。정용좌양불사성，환두포미낙납항감염치료，혈압축점회복정상。인환자항감염효과흠가，재차급여좌양불사성록화납주사액300 mg，ivgtt，qd，동시급여초분지평완석편10 mg，bid，병감측혈압，7 d후환자혈압재도승고，증가강압약용량계속사용좌양불사성6 d，환자혈압일직재고위파동。정용좌양불사성3 d후환자혈압회복정상，미재출현혈압증고。
A 75-year-old woman, hospitalized for bacterial pneumonia and pulmonary shadows with unknown origin, was administrated with intravenous drip infusion of levolfoxacin-sodium chloride injection 600 mg at the infusion rate of 1.5 mL· min-1 once daily. The patient suddenly had headache, chest tightness, nausea and vomiting after infusion. The results of general examination showed that the body temperature was 38.6 °C, blood pressure was 160/80 mm Hg, respiratory rate was 20 breaths per minute, and heart rate was regular with 82 beats per minute. Then captopril tablet 12.5 mg was given by sublingual administration immediately, and nifedipine sustained-release tablet 10 mg was administrated orally. The blood pressure decreased slightly, but it increased again next day. The levolfoxacin injection was stopped and she recieved cefminox for anti-infective therapy, the patient's BP gradually returned to normal value. Due to the poor effect of anti-infection, the patient was administrated with levolfoxacin injection (300 mg, ivgtt, qd). Nifedipine sustained-release tablet (10 mg, bid) was also used for controlling blood pressure. Seven days later, the value of blood pressure rose up again. Although the double dosage of nifedipine was used, the blood pressure lfuctuated in the high range during the next six days. Levolfoxacin was discontinued, three days later, the patient's blood pressure returned to normal, after that the blood pressure did not raise again.
