CAJ | 학술논문

1例51岁男性患者，因银屑病性关节炎口服甲氨蝶呤片，治疗过程中出现AST、ALT轻度升高，考虑药物性肝损害，给予复方甘草酸苷片2片，tid。1周后患者出现下肢乏力、行走费力，2周时出现颜面及下肢水肿，BP 160/90 mm Hg，3周时出现上肢乏力、发抖，BP 160/90 mm Hg。停药1周后乏力、行走费力、上肢发抖症状缓解，BP 130/76 mm Hg，血钾1.76 mmol· L-1、代谢性碱中毒。期间无联合用药，查甲功、肾上腺功能等未见异常。经补钾治疗5 d后患者血钾恢复至4.22 mmol· L-1，代谢性碱中毒纠正。
1례51세남성환자，인은설병성관절염구복갑안접령편，치료과정중출현AST、ALT경도승고，고필약물성간손해，급여복방감초산감편2편，tid。1주후환자출현하지핍력、행주비력，2주시출현안면급하지수종，BP 160/90 mm Hg，3주시출현상지핍력、발두，BP 160/90 mm Hg。정약1주후핍력、행주비력、상지발두증상완해，BP 130/76 mm Hg，혈갑1.76 mmol· L-1、대사성감중독。기간무연합용약，사갑공、신상선공능등미견이상。경보갑치료5 d후환자혈갑회복지4.22 mmol· L-1，대사성감중독규정。
One 51-year-old male patient with psoriasis arthritis developed elevation of AST and ALT and received compound glycyrrhizin tablets (2 tablets, tid) for the treatment of drug-induced hepatitis, which caused by methotrexate. After a week of the treatment, the patient developed weakness in lower legs and hard walking. After 2 weeks, he appeared edema in the face and lower extremity, and the blood pressure increased to 160/90 mm Hg. He suffered from upper limbs weakness and shivering, and the blood pressure was 160/90 mm Hg after 3 weeks of the treatment. After stopping use of compound glycyrrhizin for one week, the symptoms of weakness, hard walking and upper limb shaking relieved, the blood pressure returned to 130/76 mmHg, while the patient appeared hypokalemia with blood potassium 1.76 mmol?L-1 and metabolic alkalosis. The combination use of medication was not found. The functions of thyroid and adrenal were normal. After the treatment of potassium supplementation for 5 days, blood potassium recovered to 4.22 mmol?L-1, metabolic alkalosis was corrected.