CAJ | 학술논문

目的：探讨载脂蛋白AI(apolipoprotein AI，ApoAI)基因rs12721026单核苷酸多态性与长沙地区汉族人群脑出血及血脂水平的关系。方法：利用单碱基延伸技术与DNA测序结合相互印证的方法检测长沙地区汉族人群273例脑出血患者及140例正常对照的ApoAI基因rs12721026单核苷酸多态性。采用氧化酶法测定三酰甘油(TG)、总胆固醇(TC)、HDL-C及LDL-C水平。结果：脑出血组ApoAI基因rs12721026多态基因型及等位基因频率分布与对照组比较差异无统计学意义(P>0.05)；脑出血组及对照组TT基因型亚组的HDL-C水平明显高于GT/GG基因型亚组(P<0.05)，两组不同基因型亚组间TG，TC，LDL-C水平差异无统计学意义(P>0.05)。结论：ApoAI基因rs12721026多态性可能与长沙地区汉族人群脑出血的发病无关，但可能影响其HDL-C水平。
목적：탐토재지단백AI(apolipoprotein AI，ApoAI)기인rs12721026단핵감산다태성여장사지구한족인군뇌출혈급혈지수평적관계。방법：이용단감기연신기술여DNA측서결합상호인증적방법검측장사지구한족인군273례뇌출혈환자급140례정상대조적ApoAI기인rs12721026단핵감산다태성。채용양화매법측정삼선감유(TG)、총담고순(TC)、HDL-C급LDL-C수평。결과：뇌출혈조ApoAI기인rs12721026다태기인형급등위기인빈솔분포여대조조비교차이무통계학의의(P>0.05)；뇌출혈조급대조조TT기인형아조적HDL-C수평명현고우GT/GG기인형아조(P<0.05)，량조불동기인형아조간TG，TC，LDL-C수평차이무통계학의의(P>0.05)。결론：ApoAI기인rs12721026다태성가능여장사지구한족인군뇌출혈적발병무관，단가능영향기HDL-C수평。
Objective: To explore the association between apolipoprotein AI (ApoAI) gene rs12721026 polymorphism and cerebral hemorrhage (CH) in Changsha Han population, and to evaluate the effect of rs12721026 polymorphism on plasma lipid levels. <br> Methods: A total of 273 patients with CH and 140 healthy controls were collected. The rs12721026 polymorphism of ApoAI was analyzed by SNaPshot genotyping analysis and DNA sequencing. The total cholesterol (TG), triglyceride (TC), HDL-C and LDL-C were examined by oxidase method. Results: There was no significant difference in the genotype and allele frequencies of rs12721026 polymorphism between the CH group and the control group (P>0.05). Both in the CH group and in the control group, the level of HDL-C of the TT gene type of rs12721026 was significantly higher than that of the GT/GG gene type (P<0.05). There was no significant difference in the levels of TG, TC and LDL-C among different subgroups of gene types. <br> Conclusion: There may be no association between apoAI gene rs12721026 polymorphism with CH in Changsha Han population, which may still inlfuence the HDL-C levels.