CAJ | 학술논문

目的：分析机械通气患者获得性肺炎与奥美拉唑使用时间的相关性。方法选择在本院重症监护室（ ICU）接受机械性通气治疗的患者作为研究对象，分别接受奥美拉唑治疗3，5，7，15 d，比较各组的胃液pH值，应激性溃疡发生率，呼吸机相关性肺炎发生率，感染发生优势菌群情况，获得性肺炎与奥美拉唑使用时间的相关性情况。结论3 d，5 d，7 d，15 d组胃液pH值分别为（1.53±0.31），（2.74±0.74），（5.21±1.23），（6.42±1.42）；应激性溃疡发生率分别为16.67％，13.33％，10.00％，3.33％；呼吸机相关肺炎发生率分别为26.67％，33.33％，40.00％，46.67％；呼吸机相关性肺炎与应激性溃疡优势菌群符合率高达50％。结论奥美拉唑使用时间与胃液pH值、呼吸机相关性肺炎发生例数呈正相关，与应激性溃疡发生例数呈负相关。
목적：분석궤계통기환자획득성폐염여오미랍서사용시간적상관성。방법선택재본원중증감호실（ ICU）접수궤계성통기치료적환자작위연구대상，분별접수오미랍서치료3，5，7，15 d，비교각조적위액pH치，응격성궤양발생솔，호흡궤상관성폐염발생솔，감염발생우세균군정황，획득성폐염여오미랍서사용시간적상관성정황。결론3 d，5 d，7 d，15 d조위액pH치분별위（1.53±0.31），（2.74±0.74），（5.21±1.23），（6.42±1.42）；응격성궤양발생솔분별위16.67％，13.33％，10.00％，3.33％；호흡궤상관폐염발생솔분별위26.67％，33.33％，40.00％，46.67％；호흡궤상관성폐염여응격성궤양우세균군부합솔고체50％。결론오미랍서사용시간여위액pH치、호흡궤상관성폐염발생례수정정상관，여응격성궤양발생례수정부상관。
Objective To analyze the correlation of acquired pneumonia in patients receiving ICU mechanical ventilation and omeprazole use time.Methods One hundred and twenty patients with ICU receiving mechanical ventilation were randomized chosen to receive omeprazole treatment for 3, 5, 7, 15 d.Gastric pH value, stress ulcer incidence , ventilator associated pneumonia incidence , infection dominant flora were compared;correlation of acquired pneumonia and the omeprazole use time was analyzed.Results 3 d group, 5 d group, 7 d group, 15 d group gastric juice pH were respectively ( 1.53 ±0.31 ) , ( 2.74 ±0.74 ) , (5.21 ±1.23 ) , ( 6.42 ±1.42 ); the incidences of stress ulcer were 16.67%, 13.33%, 10.00%, 3.33%;the incidence of ventilator asso-ciated pneumonia were 26.67%, 33.33%, 40%, 46.67%;ventilator-associated pneumonia and stress ulcer dominant flora compliance incidence rate was as high as 50%.Conclusion Omeprazole use of time is posi-tively correlated with gastric pH value , ventilator -associated pneumonia cases , and negatively correlated with the number of stress ulcer cases.