CAJ | 학술논문

利用FMOC化学固相多肽合成法合成了3种含精氨酸的小分子硼酸肽（标记为BPs（1．3））。在生理pH下，含阳离子的硼酸肽可自组装形成有序超分子纳米组装体。二羟基酚染料茜素红与硼酸肽可特异性结合形成五元环硼酸酯，伴随荧光和颜色的显著变化，可进一步调控硼酸肽的自组装行为。通过扫描电镜研究茜素红调控前后硼酸肽的自组装形态，并用红外光谱和圆二色谱研究其自组装机理。结果表明，3种含精氨酸硼酸肽在生理pH下可自组装形成不同的超分子纳米组装体。通过茜素红的调控，茜素红／硼酸肽化合物，可自组装形成更有序，更精致的超分子聚集体。
이용FMOC화학고상다태합성법합성료3충함정안산적소분자붕산태（표기위BPs（1．3））。재생리pH하，함양리자적붕산태가자조장형성유서초분자납미조장체。이간기분염료천소홍여붕산태가특이성결합형성오원배붕산지，반수형광화안색적현저변화，가진일보조공붕산태적자조장행위。통과소묘전경연구천소홍조공전후붕산태적자조장형태，병용홍외광보화원이색보연구기자조장궤리。결과표명，3충함정안산붕산태재생리pH하가자조장형성불동적초분자납미조장체。통과천소홍적조공，천소홍／붕산태화합물，가자조장형성경유서，경정치적초분자취집체。
Three arginine-containing oligo-borono-peptides （BPs （1-3）） were synthesized by employing a standard FMOC chemistry SPPS. BPs（1-3） could spontaneously self-assemble into supramolecular architectures at a physiological environment. With recognition between BPs and alizarin red S （ARS） , the five-membered ring borate esters （ARS/BPs） could be formed with dramatic changes in fluorescent feature and visible color. These self-assembled supramolecular archi- tectures were observed by scanning electron microscope （SEM） and their self-assembly mechanisms were explored by Fou- rier Transform Infrared Spectroscopy （FT-IR） and Circular Dichroism （CD）. It was found that BPs were capable of self- assembling into well-ordered supramolecular architectures, and after recognition of ARS, ARS/BPs could further self-as- semble into more ordered and sophisticated supramolecular architectures.