CAJ | 학술논문

智能响应型材料能够感受来自外界的刺激，导致某些物理或者化学性能发生显著的变化，因而有着广泛的研究和应用，尤其是在生物医用材料领域。除传统的温度、光、pH、磁响应方式以外，主要综述了几种生物信号响应型材料，例如生物分子、酶、葡萄糖，以及多重响应型材料；着重介绍用作基因或药物载体的材料。关注不同响应方式的智能材料与细胞之间的相互作用，包括智能响应型微粒的胞吞、胞内转运、细胞内的分布以及响应，和微粒的响应性变化过程比如体积的膨胀收缩，而非材料本身性质与细胞的相互作用。这些结果有利于在细胞和亚细胞层次上理解响应性材料在基因和药物控释中的生物相容性等问题，从而更好地设计载体材料。
지능향응형재료능구감수래자외계적자격，도치모사물리혹자화학성능발생현저적변화，인이유착엄범적연구화응용，우기시재생물의용재료영역。제전통적온도、광、pH、자향응방식이외，주요종술료궤충생물신호향응형재료，례여생물분자、매、포도당，이급다중향응형재료；착중개소용작기인혹약물재체적재료。관주불동향응방식적지능재료여세포지간적상호작용，포괄지능향응형미립적포탄、포내전운、세포내적분포이급향응，화미립적향응성변화과정비여체적적팽창수축，이비재료본신성질여세포적상호작용。저사결과유리우재세포화아세포층차상리해향응성재료재기인화약물공석중적생물상용성등문제，종이경호지설계재체재료。
Intelligent-responsive materials exhibit abrupt changes of physical and/or chemical properties in response to external stimuli. This kind of materials is of great importance in both basic researches and applications, especially in the field of biomedical materials. Besides the traditional photo-, pH-, magnetic-responsive materials, this article briefly sum- marizes materials responding to several types of biological signals including enzymes, glucose and other biomolecules. The materials with multi-responsive properties are emphasized with respect to the applications for gene and drug delivery. New breakthroughs are introduced on the interactions between the intelligent materials and cells, such as cellular uptake, intra- cellular transportation and distribution as well as responsivity. The importance of specific stimuli-responsivity such as vol- ume expansion and contraction is envisaged in terms of cells-particles interaction. This would be intriguing to understand the biocompatibility and some other issues of the stimuli-responsive particles, which in turn can guide the design of deliv- ery carriers of better biological performance.