中国材料进展
中國材料進展
중국재료진전
MATERIALS CHINA
2012年
6期
12-18,55
,共8页
诊疗制剂%诊断%治疗%纳米粒子
診療製劑%診斷%治療%納米粒子
진료제제%진단%치료%납미입자
theranostic agent%dagnosis%therapy%nanoparticles
癌症是一种具有高度异质性和极强适应性的疾病,需要根据病人的特点和疾病的进展选择不同类型的诊断和治疗方案。诊疗时联用纳米制剂能为患者提供各种个性化的诊断治疗方案,从而改善治疗效果。因此,研发新型多功能纳米诊疗制剂具有重要的意义。介绍了当前常用的诊断制剂和适用的治疗方法,诊断制剂包括x射线计算机断层扫描造影剂、超声造影剂、磁共振造影剂以及正电子发射断层扫描造影剂等,治疗方法包括化疗、放疗、光动力治疗、光热治疗以及基因治疗等。综述了近年来文献报道的各种典型的纳米诊疗制剂,并提出了诊疗制剂研究中存在的问题和今后可能的发展方向。
癌癥是一種具有高度異質性和極彊適應性的疾病,需要根據病人的特點和疾病的進展選擇不同類型的診斷和治療方案。診療時聯用納米製劑能為患者提供各種箇性化的診斷治療方案,從而改善治療效果。因此,研髮新型多功能納米診療製劑具有重要的意義。介紹瞭噹前常用的診斷製劑和適用的治療方法,診斷製劑包括x射線計算機斷層掃描造影劑、超聲造影劑、磁共振造影劑以及正電子髮射斷層掃描造影劑等,治療方法包括化療、放療、光動力治療、光熱治療以及基因治療等。綜述瞭近年來文獻報道的各種典型的納米診療製劑,併提齣瞭診療製劑研究中存在的問題和今後可能的髮展方嚮。
암증시일충구유고도이질성화겁강괄응성적질병,수요근거병인적특점화질병적진전선택불동류형적진단화치료방안。진료시련용납미제제능위환자제공각충개성화적진단치료방안,종이개선치료효과。인차,연발신형다공능납미진료제제구유중요적의의。개소료당전상용적진단제제화괄용적치료방법,진단제제포괄x사선계산궤단층소묘조영제、초성조영제、자공진조영제이급정전자발사단층소묘조영제등,치료방법포괄화료、방료、광동력치료、광열치료이급기인치료등。종술료근년래문헌보도적각충전형적납미진료제제,병제출료진료제제연구중존재적문제화금후가능적발전방향。
Cancer is a highly heterogeneous and adaptable disease, therefore, diverse types of treatment options need to be chosen depending on patient characteristics and disease progression. Theranostic nanoparticles provide patients with va- rious treatment options that are suitable for individuals, and thereby result in improved prognosis. So it is important to de- velop novel multifunctional nano-theranostic agents. Commonly used diagnostic agents and treatment methods were intro- duced, such as diagnostic agents including X-ray computed tomography contrast agents, ultrasound contrast agents, MRI contrast agents and positron emission tomography imaging agents. Treatment methods include chemotherapy, radiotherapy, photodynamic therapy, photothermal therapy and gene therapy. A variety of typical nano-theranostic agents reported in re- cent years were reviewed, and the problems existed in the studies of theranostics and the possibly future development di- rection were also proposed.