CAJ | 학술논문

目的：探讨臭氧化自体血治疗痛风患者疼痛的有效性和安全性，期望为痛风患者提供新的治疗方法。方法选取2011年9月-2012年6月我院收治的有疼痛症状的痛风患者10例，臭氧化自体血治疗浓度为20μg/ml，每周3次，共计10次。采集治疗前、治疗第5次后和治疗第10次后的全血和血清，记录患者视觉模拟评分（ VAS）的变化，随访6个月观察不良事件和不良反应。结果治疗前、治疗第5次后和治疗第10次后血小板计数（ PLT）、单核细胞计数（ MONO）、肌酐、尿酸、低密度脂蛋白（ LDL）水平比较，差异均无统计学意义（ P>0.05）。治疗第5次后和治疗第10次后VAS较治疗前降低（ P<0.05）。患者一般耐受性良好，无死亡病例，无严重不良事件发生。1例患者出现轻度不良反应（在治疗第7次后感觉轻度头晕和恶心，2 h后恢复正常）；随访6个月内痛风患者疼痛复发率为30%（3/10）。结论臭氧化自体血治疗可以缓解痛风患者的疼痛，具有镇痛的作用；患者耐受性良好，安全，没有严重不良反应；对于有合并症、药物治疗有禁忌证的痛风患者，可以作为缓解疼痛症状的一种新的治疗选择。
목적：탐토취양화자체혈치료통풍환자동통적유효성화안전성，기망위통풍환자제공신적치료방법。방법선취2011년9월-2012년6월아원수치적유동통증상적통풍환자10례，취양화자체혈치료농도위20μg/ml，매주3차，공계10차。채집치료전、치료제5차후화치료제10차후적전혈화혈청，기록환자시각모의평분（ VAS）적변화，수방6개월관찰불량사건화불량반응。결과치료전、치료제5차후화치료제10차후혈소판계수（ PLT）、단핵세포계수（ MONO）、기항、뇨산、저밀도지단백（ LDL）수평비교，차이균무통계학의의（ P>0.05）。치료제5차후화치료제10차후VAS교치료전강저（ P<0.05）。환자일반내수성량호，무사망병례，무엄중불량사건발생。1례환자출현경도불량반응（재치료제7차후감각경도두훈화악심，2 h후회복정상）；수방6개월내통풍환자동통복발솔위30%（3/10）。결론취양화자체혈치료가이완해통풍환자적동통，구유진통적작용；환자내수성량호，안전，몰유엄중불량반응；대우유합병증、약물치료유금기증적통풍환자，가이작위완해동통증상적일충신적치료선택。
Objective To investigate the effectiveness and safety of ozonated autologous blood in treatment of patients with gout,and to expect to provide a new therapeutic method for patients with gout. Methods Ten patients with gout who were admitted to our hospital from September 2011 to June 2012 were selected as study subjects,patients were treated with ozonated autologous blood,the concentration of ozonated autologous blood was 20μg/ml,3 times per week,10 times totally. Whole blood and plasma samples were collected before treatment,after fifth and tenth course of treatment,respectively. VAS was recorded, adverse events and reactions were observed. Follow-up period was six months. Results Before treatment,after fifth and tenth course of treatment,there was no significant difference in the indexes of PLT,MONO,Cr,UA and LDL(P >0. 05). The VAS after fifth and tenth course of treatment was significantly lower than that before treatment( P<0. 05 ) . The therapy is well tolerated by patients. No death and serious adverse events occurred during the study. One case had mild adverse reactions( The pa-tient feeled dizzy and sick after seventh course of treatment and recovered after 2 hours). The recurrence rate of pain was 30%(3/10)after six months of follow-up. Conclusion Ozonated autologous blood therapy could relieve the pain effectively in pa-tients with gout. The patients tolerate the therapy well and the therapy is safe with no serious adverse reactions. Ozonated autologous blood therapy could be selected as a novel therapeutic method for gouty patients with complication and drug contraindication.