CAJ | 학술논문

背景维吾尔族有独特的遗传背景，其抑郁症易患基因表达可能与其他民族存在着很大的差异。细胞因子在抑郁症的发病机制中起重要作用，细胞因子基因多态性可能通过影响细胞因子的产生导致神经内分泌的改变从而引起抑郁症状。寻找白介素1β（ IL-1β）基因中可能具有抑郁症易患性的单核苷酸多态性（ SNP）位点，探讨维吾尔族抑郁症潜在致病基因的差异，为寻求诊断、个体化治疗和预防提供更广的思路。目的探讨IL-1β基因rs1143634和rs3136558位点多态性与新疆维吾尔族抑郁症的相关性。方法选取2012年1月-2013年10月在新疆医科大学第一附属医院心理医学科住院的维吾尔族抑郁症患者100例为抑郁症组，体检中心无精神疾病史、无精神病药物治疗史、无物质滥用史、无神经系统疾病或损伤史者120例为对照组，采用聚合酶链反应-限制性片段长度多态性方法检测受试者IL-1β基因rs1143634和rs3136558位点基因型和等位基因频率分布情况。结果抑郁症组和对照组rs1143634位点和rs3136558位点CC、CT和TT基因型分布比较，差异无统计学意义（ P>0.05）；C和T等位基因频率比较，差异亦无统计学意义（P>0.05）。结论 IL-1β基因rs1143634和rs3136558位点基因多态性与新疆维吾尔族抑郁症的发生无明显相关性。
배경유오이족유독특적유전배경，기억욱증역환기인표체가능여기타민족존재착흔대적차이。세포인자재억욱증적발병궤제중기중요작용，세포인자기인다태성가능통과영향세포인자적산생도치신경내분비적개변종이인기억욱증상。심조백개소1β（ IL-1β）기인중가능구유억욱증역환성적단핵감산다태성（ SNP）위점，탐토유오이족억욱증잠재치병기인적차이，위심구진단、개체화치료화예방제공경엄적사로。목적탐토IL-1β기인rs1143634화rs3136558위점다태성여신강유오이족억욱증적상관성。방법선취2012년1월-2013년10월재신강의과대학제일부속의원심리의학과주원적유오이족억욱증환자100례위억욱증조，체검중심무정신질병사、무정신병약물치료사、무물질람용사、무신경계통질병혹손상사자120례위대조조，채용취합매련반응-한제성편단장도다태성방법검측수시자IL-1β기인rs1143634화rs3136558위점기인형화등위기인빈솔분포정황。결과억욱증조화대조조rs1143634위점화rs3136558위점CC、CT화TT기인형분포비교，차이무통계학의의（ P>0.05）；C화T등위기인빈솔비교，차이역무통계학의의（P>0.05）。결론 IL-1β기인rs1143634화rs3136558위점기인다태성여신강유오이족억욱증적발생무명현상관성。
Background Uygur population has a unique genetic background,the susceptibility gene for depressive disorder of Uygur population may differ from that of other races. Cytokines play an important role in the pathogenesis of depressive disorder. The polymorphism of cytokines may affect the production of cytokines, thus neuroendocrine changes and depressive symptoms occur. Exploring the suspect SNPs in the IL-1βgene and discussing the race differences for depressive disorder poten-tial pathogenic genes between Uygur and other races may contribute to the diagnosis,individual treatment and prevention for de-pressive disorder. Objective To explore the relationship between IL-1βgene rs1143634,rs3136558 site polymorphism and de-pressive disorder among Uighurs in Xinjiang. Methods A total of 100 Uighurs with depressive disorder who were admitted to de-partment of psychological medicine,the First Affiliated Hospital of Xinjiang Medical University,were selected as depressive dis-order group,and 120 physical examinees without history of mental illness,psychiatric medications,drug abuse,nervous system diseases and injuries were selected as control group. The genotype and allele frequency distribution of IL-1β gene rs1143634, rs3136558 site were detected by using polymerase chain reaction and restriction fragment length polymorphism( RFLP-PCR). Results There was no significant difference in rs1143634,rs3136558 site CC,CT,TT genotype distribution between depres-sive disorder group and control group(P>0. 05). There was no significant difference in C,T allele frequencies(P>0. 05). Conclusion The findings suggest no significant association was found between IL-1βgene rs1143634,rs3136558 site polymor-phism and depressive disorder among Uighurs in Xinjiang.