CAJ | 학술논문

目的了解疫苗不良反应(ADR)的发生情况.方法对汕头市不良反应中心提供的广东省2006-2009年473例疫苗ADR报告中患者的年龄、ADR的类型、临床表现及涉及系统等信息进行统计分析.结果共涉及疫苗种类24个品种,以吸附无细胞百日咳、白喉、破伤风联合疫苗构成比最大,为22.0％(104/473);发生于各个年龄段,1个月～3岁构成比较高,达275例,占58.1％(275/473);ADR类型以一般反应为主,涉及多个系统/器官损害;临床表现以全身性损害、皮肤及其附件损害占最大比例,分别为31.4％(255/811)和18.4％(149/811).结论疫苗ADR的发生情况以一般反应为主,其绝大多数经常规处理后可好转或康复,死亡和后遗症发生较少,但仍应引起重视,做好安全接种及不良反应监测工作.
목적 료해역묘불량반응(ADR)적발생정황.방법 대산두시불량반응중심제공적광동성2006-2009년473례역묘ADR보고중환자적년령、ADR적류형、림상표현급섭급계통등신식진행통계분석.결과 공섭급역묘충류24개품충,이흡부무세포백일해、백후、파상풍연합역묘구성비최대,위22.0％(104/473);발생우각개년령단,1개월～3세구성비교고,체275례,점58.1％(275/473);ADR류형이일반반응위주,섭급다개계통/기관손해;림상표현이전신성손해、피부급기부건손해점최대비례,분별위31.4％(255/811)화18.4％(149/811).결론 역묘ADR적발생정황이일반반응위주,기절대다수경상규처리후가호전혹강복,사망화후유증발생교소,단잉응인기중시,주호안전접충급불량반응감측공작.
Objective To investigate the adverse reactions of vaccine.Methods The report of 473 adverse reaction cases of vaccine from 2006 to 2009 was provided by the Adverse Reaction (ADR) Center of Shantou City.Some information of the report such as the age,types of ADR,clinical Manifestation as well as vaccine-immune system were analyzed.Results There were 24 kinds of vaccine involved in ADR,and the DPT vaccine contributed to the highest proportion [22.0％ (104/473)].Adverse reaction occurred in all age groups and the 3-5 age group had 275 cases which accounted for a high proportion (58.1％).The general reactions were the main type of ADR,including the damage of many systems/organs.The main clinical manifestation was systemic lesions (31.4％),as well as skin damage(18.4％).Conclusions General reaction is the main type of ADR and most of the patients can recover or be improved.However,attention should be paid to the safe vaccination and the surveillance of ADR.