CAJ | 학술논문

目的：探讨米非司酮联合米索前列醇治疗稽留流产的疗效及安全性。方法选择68例稽留流产患者作为观察组，早、晚空腹各服米非司酮50 mg，共2 d，第3天口服米索前列醇0.6 mg，妊娠组织物自然排出后，行清宫术。抽取病例资料中70例稽留流产患者为对照组，治疗方法为口服己烯雌酚5 mg，3次/天，共3 d，静滴缩宫素，胚胎组织物自然排出后行清宫术，比较两组患者术中术后情况。结果观察组患者宫腔内组织物自然排出率明显高于对照组（ P＜0.01）；观察组不良反应发生率、人工流产手术综合征发生率、出血量均明显低/少于对照组（ P＜0.01）。结论米非司酮与米索前列醇配合清宫术治疗稽留流产疗效好，安全性高，值得推广。
목적：탐토미비사동연합미색전렬순치료계류유산적료효급안전성。방법선택68례계류유산환자작위관찰조，조、만공복각복미비사동50 mg，공2 d，제3천구복미색전렬순0.6 mg，임신조직물자연배출후，행청궁술。추취병례자료중70례계류유산환자위대조조，치료방법위구복기희자분5 mg，3차/천，공3 d，정적축궁소，배태조직물자연배출후행청궁술，비교량조환자술중술후정황。결과관찰조환자궁강내조직물자연배출솔명현고우대조조（ P＜0.01）；관찰조불량반응발생솔、인공유산수술종합정발생솔、출혈량균명현저/소우대조조（ P＜0.01）。결론미비사동여미색전렬순배합청궁술치료계류유산료효호，안전성고，치득추엄。
Objective To investigate the efficacy and safety of mifepristone combined with misoprostol in the treatment of missed abortion.Methods 68 patients of missed abortion were taken as the observation group and given 50mg of mifepristone in the morning and evening respectively for two days.On the third day, they were given 0.6 mg of misoprostol orally and then received complete curet-tage of uterine cavity after the gestation tissue was drained naturally.70 missed abortion patients were taken as the control group, which were treated with 5mg diethylstilbestrol, three times daily for three days.Oxytocin was injected into the vein, and complete curettage of uterine cavity was carried out after the gestation tissue was drained naturally.The two groups of the patients were compared and ob-served after the operation .Results The natural drain rate of the tissue inside the uterine cavity of the observation group is obviously higher than that of the control group (P<0.01).The adverse effects rate, syndrome of induced abortion operation and the amount of bleeding are all lower than that of the control group ( P<0.01 ) .Conclusion The mifepristone combined with misoprostol in the treat-ment of missed abortion is safe and effective, and this therapy is worth promoting.