CAJ | 학술논문

目的采用COX风险模型对154例胰腺癌进行统计分析,探讨影响胰腺癌预后的因素.方法回顾分析2001年4月-2008年4月福建医科大学附属协和医院收治的154例胰腺癌患者的临床资料,应用Kaplan-Meier法计算生存率,生存曲线采用Log-rank检验,多因素分析采用COX比例风险模型.结果 154例患者生存期为1～ 106个月,中位生存期8个月,其中6、12、18、36个月生存率分别为58.4％、29.2％、16.3％、3.7％.多因素分析显示,TNM分期、手术方式、综合治疗是影响胰腺癌预后的独立因素.结论胰腺癌患者预后受多个因素影响,TNM分期越晚的胰腺癌患者预后越差,行根治性切除术及综合治疗的患者预后较好.
목적 채용COX풍험모형대154례이선암진행통계분석,탐토영향이선암예후적인소.방법 회고분석2001년4월-2008년4월복건의과대학부속협화의원수치적154례이선암환자적림상자료,응용Kaplan-Meier법계산생존솔,생존곡선채용Log-rank검험,다인소분석채용COX비례풍험모형.결과 154례환자생존기위1～ 106개월,중위생존기8개월,기중6、12、18、36개월생존솔분별위58.4％、29.2％、16.3％、3.7％.다인소분석현시,TNM분기、수술방식、종합치료시영향이선암예후적독립인소.결론 이선암환자예후수다개인소영향,TNM분기월만적이선암환자예후월차,행근치성절제술급종합치료적환자예후교호.
Objective To explore the factors affecting the prognosis of pancreatic cancer patients,using COX risk model to carry on the statistical analysis of 154 cases of pancreatic carcinoma.Methods Retrospectively analyzed 154 pancreatic cancer cases' history date treated in April 2001-April 2008 of Fujian Medical University Union Hospital.Survival rate was caculated by Kaplan-Meier estimation while survival cruve was analysed by Log-rank test.Prognostic factors were studied by multivariate analysis with COX proportional hazards survival model.Results In this group,survival time was from 1 to 106 months and the median survival time was 8 months.Overall survival rates at 6 months,12 months,18 months,36 months were 58.4％,29.2％,16.3％ and 3.7％ respectively.Multivariate revealed that independent prognostic factors were follows:TNM tumor staging,operation mode and synthetic therapy.Conclusions The prognosis of patients with pancreatic carcinoma is determined by multiple factors.Patients of advanced TNM staging have a poorer prognosis.Radical resection and comprehensive treatment of patients prognosis is better.