药物不良反应杂志
藥物不良反應雜誌
약물불량반응잡지
ADVERSE DRUG REACTIONS JOURNAL
2013年
4期
235
,共1页
驱白巴布期片%药物性肝损伤
驅白巴佈期片%藥物性肝損傷
구백파포기편%약물성간손상
Qubai Babuqi tablet%Drug-induced liver injury
1例21岁男性患者因患白癜风口服驱白巴布期片1.5g,3次/d.2个月后,患者出现全身皮肤及巩膜黄染,尿液呈浓茶色.实验室检查:总胆红素(TBil) 540.7μmol/L,直接胆红素(DBil)365.3 μmol/L,丙氨酸转氨酶390 U/L,天冬氨酸转氨酶553 U/L,γ-L-谷氨酰转肽酶(γ-GT)102 U/L,碱性磷酸酶208 U/L,甲胎蛋白(AFP) 1147 μg/L.停用驱白巴布期片,给予保肝药物治疗.10周后复查,TBil 34.6 μmol/L,DBil 15.7 μmol/L,γ-GT 122 U/L,AFP 9.4 μg/L.
1例21歲男性患者因患白癜風口服驅白巴佈期片1.5g,3次/d.2箇月後,患者齣現全身皮膚及鞏膜黃染,尿液呈濃茶色.實驗室檢查:總膽紅素(TBil) 540.7μmol/L,直接膽紅素(DBil)365.3 μmol/L,丙氨痠轉氨酶390 U/L,天鼕氨痠轉氨酶553 U/L,γ-L-穀氨酰轉肽酶(γ-GT)102 U/L,堿性燐痠酶208 U/L,甲胎蛋白(AFP) 1147 μg/L.停用驅白巴佈期片,給予保肝藥物治療.10週後複查,TBil 34.6 μmol/L,DBil 15.7 μmol/L,γ-GT 122 U/L,AFP 9.4 μg/L.
1례21세남성환자인환백전풍구복구백파포기편1.5g,3차/d.2개월후,환자출현전신피부급공막황염,뇨액정농다색.실험실검사:총담홍소(TBil) 540.7μmol/L,직접담홍소(DBil)365.3 μmol/L,병안산전안매390 U/L,천동안산전안매553 U/L,γ-L-곡안선전태매(γ-GT)102 U/L,감성린산매208 U/L,갑태단백(AFP) 1147 μg/L.정용구백파포기편,급여보간약물치료.10주후복사,TBil 34.6 μmol/L,DBil 15.7 μmol/L,γ-GT 122 U/L,AFP 9.4 μg/L.
A 21-year-old male patient received Qubai Babuqi tablet 1.5 g thrice daily for vitiligo.Two months later,he developed jaundice of skin and sclera,and dark urine.Laboratory tests showed the following values:total bilirubin (TBil) 540.7 μmol/L,direct bilirubin (DBil) 365.3 μmol/L,alanine transaminase 390 U/L,aspartate transaminase 553 U/L,γ-glutamyl transferase (γ-GT) 102 U/L,alkaline phosphatase 208 U/L,and alpha-fetoprotein (AFP) 1147 μg/L.Qubai Babuqi tablet was stopped.He was given liver-protective drugs.Ten weeks later,repeat laboratory tests showed the following values:TBil 34.6μmol/L,DBil 15.7 μmol/L,γ-GT 122 U/L,and AFP 9.4 μg/L.
