CAJ | 학술논문

IgA肾病是全球范围内最为常见的原发性肾小球疾病，目前公认其是一种免疫介导性炎症疾病，但具体发病机制尚不清楚。幽门螺杆菌（ Hp）是一种定植于人类胃肠道的微需氧革兰阴性菌，幽门螺杆菌感染能引起急慢性的炎症免疫反应。近年来研究发现Hp感染与IgA肾病之间存在一定的联系，Hp可能是IgA肾病的潜在致病原之一。相关研究已成为目前学术界的热点。该文结合国内外和四川大学生物治疗国家重点实验室团队的研究，就HP感染与IgA肾病的发生发展机制进行了论述。
IgA신병시전구범위내최위상견적원발성신소구질병，목전공인기시일충면역개도성염증질병，단구체발병궤제상불청초。유문라간균（ Hp）시일충정식우인류위장도적미수양혁란음성균，유문라간균감염능인기급만성적염증면역반응。근년래연구발현Hp감염여IgA신병지간존재일정적련계，Hp가능시IgA신병적잠재치병원지일。상관연구이성위목전학술계적열점。해문결합국내외화사천대학생물치료국가중점실험실단대적연구，취HP감염여IgA신병적발생발전궤제진행료논술。
IgAnephropathyisthemostcommonprimaryglomerulardiseaseworldwidewhichis recognized as a kind of immune-mediated inflammatory disease although its pathogenesis is not clear yet. Helicobacter pylori( Hp ) is a kind of microaerobic gram-negative bacterium colonized in human gastrointestinal tract. Hp infection can cause acute or chronic immune inflammation. In recent years,it has been found that there is a certain relationship between Hp infection and IgA nephropathy,and that Hp is likely to be one of the potential pathogenic agents of IgA nephropathy,and related research has become a hot spot of academia. Whether Hp infection is associated with the development and progression of IgA nephropathy has become a hot spot of research. This review will discuss HP infection and pathological mechanism of IgA nephropathy,synthesizing domestic and international results including our own.