CAJ | 학술논문

目的：探讨颈动脉、同型半胱氨酸、酯蛋白（a）诊断作为预测冠状动脉粥样硬化性心脏病（简称冠心病）诊断指标的临床可行性。方法对经冠脉造影确诊191例冠心病患者，做双侧颈动脉彩色超声检查及同型半胱氨酸、酯蛋白（a）水平测定，研究颈动脉与同型半胱氨酸、酯蛋白（a）在预测冠心病的可行性。结果根据颈动脉彩超检查结果显示72．25％的冠心病患者颈动脉处增厚形成斑块，斑块的发生率达62．72％。有斑块患者的同型半胱氨酸、酯蛋白（a）指标高于没有斑块患者P＜0．05。结论颈动脉彩超检测结合同型半胱氨酸、酯蛋白（a）检测对冠心病的预测性诊断具有一定的指导性，但作为预测性诊断的标准仍需要大量的临床试验和科学的理论基础。
목적：탐토경동맥、동형반광안산、지단백（a）진단작위예측관상동맥죽양경화성심장병（간칭관심병）진단지표적림상가행성。방법대경관맥조영학진191례관심병환자，주쌍측경동맥채색초성검사급동형반광안산、지단백（a）수평측정，연구경동맥여동형반광안산、지단백（a）재예측관심병적가행성。결과근거경동맥채초검사결과현시72．25％적관심병환자경동맥처증후형성반괴，반괴적발생솔체62．72％。유반괴환자적동형반광안산、지단백（a）지표고우몰유반괴환자P＜0．05。결론경동맥채초검측결합동형반광안산、지단백（a）검측대관심병적예측성진단구유일정적지도성，단작위예측성진단적표준잉수요대량적림상시험화과학적이론기출。
Objective To investigate the clinical feasibility of using carotid artery,lipoprotein(a)[LP(a)]and plaques homocys-teine(Hcy)as the diagnostic indicators for coronary atherosclerotic heart disease(CHD).Methods 191cases of CHD confirmed with coro-nary angiograpHy were given bilateral carotid color Doppler ultrasound examination,LP(a)and Hcy,The feasibility of using neck artery plaque score,LP(a)and Hcy as prediction indicators for cormary heart disease was studied.Results Carotid colr Doppler ultrasound exami-nation results showed 72.25% of coronary heart disease patients demonstrated carotid artery thickening and plaque formation,with a plaque occurrence rate of 62.72%.LP(a)and Hcy was significantly higher in patients with plaque than in patients without plaque (P<0.05 ). Conclusion catotid ultrasonograpHy detection combined with LP(a)and Hcy test can provide guidance for the predictive diangnosis of coro-nary artery disease,but the criteria of prediction with both indicators still need to be based on a large number of clinical trials and scientific theorrtical foundation.