CAJ | 학술논문

目的：测定急性脑梗死患者巨噬细胞移动抑制因子（ MIF）水平，分析MIF与脑梗死病情程度之间的相关性。方法选取急性脑梗死患者60例和正常对照组19例。采用双抗体夹心ELISA法检测血清MIF水平。同时检查、记录患者的入院和出院NIHSS评分，判断MIF与临床资料之间的相关性。结果与正常对照组比较，脑梗死组血清MIF水平明显降低，且轻、中、重度脑梗死组血清MIF水平均低于正常对照组。脑梗死患者血清MIF与NIHSS评分之间未发现明显相关关系；但随着脑梗死程度的加重，血清MIF水平有进一步降低的趋势。结论急性脑梗死患者血清MIF水平明显降低，在一定程度上反映了病情的严重程度，进一步证实炎症机制参与了脑梗死的病理过程。
목적：측정급성뇌경사환자거서세포이동억제인자（ MIF）수평，분석MIF여뇌경사병정정도지간적상관성。방법선취급성뇌경사환자60례화정상대조조19례。채용쌍항체협심ELISA법검측혈청MIF수평。동시검사、기록환자적입원화출원NIHSS평분，판단MIF여림상자료지간적상관성。결과여정상대조조비교，뇌경사조혈청MIF수평명현강저，차경、중、중도뇌경사조혈청MIF수평균저우정상대조조。뇌경사환자혈청MIF여NIHSS평분지간미발현명현상관관계；단수착뇌경사정도적가중，혈청MIF수평유진일보강저적추세。결론급성뇌경사환자혈청MIF수평명현강저，재일정정도상반영료병정적엄중정도，진일보증실염증궤제삼여료뇌경사적병리과정。
Objective To detect the serum macrophage migration inhibitory factor ( MIF) level in patients with acute cerebral infarction and correlation with the severity of neurological deficiency .Methods 60 patients with acute cerebral infarction and 19 healthy normal control were selected .Serum MIF levels were detected using a double antibody sandwich ELISA .Meanwhile , the patient's admission and discharge NIHSS scores were recorded .Correlation was detected between MIF levels and NIHSS scores .Results The serum MIF decreased significantly in the cerebral infarction group compared to normal control group .Serum MIF levels in mild , medium, severe infarction groups were all significantly lower than that in the normal control group .In cerebral infarction group , no significant correlation was found between serum MIF levels and NIHSS scores;but the tendency was found in MIF level to decrease progressively with the severity of cerebral infarction .Conclusion The serum MIF decrease significantly in patients with acute cerebral infarction.MIF involves in the pathophysiology of cerebral infarction , the MIF level can reflect the severity of cerebral infarction to some extent .