CAJ | 학술논문

目的：观察急性脑出血患者基质金属蛋白酶-9（ MMP-9）的表达及依达拉奉干预效应的临床疗效。方法80例急性脑出血患者随机分为治疗组和对照组各40例。对照组给予常规治疗，治疗组在对照组治疗基础上加用依达拉奉，并在治疗后24h内和14d进行神经功能缺损评分及血浆MMP-9水平测定。结果治疗组神经功能缺损评分、血浆MMP-9水平较对照组降低（ P＜0．05、P＜0．01）。结论依达拉奉可改善急性脑出血患者神经功能，可能与降低MMP-9水平有关。
목적：관찰급성뇌출혈환자기질금속단백매-9（ MMP-9）적표체급의체랍봉간예효응적림상료효。방법80례급성뇌출혈환자수궤분위치료조화대조조각40례。대조조급여상규치료，치료조재대조조치료기출상가용의체랍봉，병재치료후24h내화14d진행신경공능결손평분급혈장MMP-9수평측정。결과치료조신경공능결손평분、혈장MMP-9수평교대조조강저（ P＜0．05、P＜0．01）。결론의체랍봉가개선급성뇌출혈환자신경공능，가능여강저MMP-9수평유관。
Objective To observe the clinical efficacy of edaravone for acute cerebral hemorrhage and its impact on serum content of MMP-9.Methods A total of 80 patients were enrolled:40(control group) were randomly assigned to receive routine therapy alone, and 40 (trial group) to receive routine therapy plus edaravone.The nerve function neurological deficst, serum content of MMP-9 were compared 14d before and after treatment.Results In the trial group as compared with the control group, the nerve function deficiency scores were obviously lower (P<0.05), and serum content of MDA was significantly lower (P<0.05).Conclusion Edaravone can obviously improve the nerve function of patients with acute cerebral hemorrhage, this may be attributed to the low content of MMP-9.