CAJ | 학술논문

目的：分析中青年进展性脑卒中患者的危险因素。方法根据病情，将同时期29～60岁急性缺血性脑卒中患者140例，为低分子肝素急性卒中试验（ TOAST）分型大、小血管病变型，分为进展性卒中组70例，即研究组；完全性卒中患者70例，即对照组。比较研究组和对照组的一般资料、生物化学指标及头颅影像学的不同。结果高血压病史、嗜酒史、入院时所测收缩压、大血管病变、低密度脂蛋白、超敏C反应蛋白（hs-CRP）及同型半胱氨酸（Hcy）浓度两组间比较差异有统计学意义（P＜0．05，P＜0．01）；多元逐步回归分析发现血清Hcy浓度、hs-CRP浓度及LDL正相关。结论中青年患者进展性卒中的危险因素为高血压病史、嗜酒史、大血管病变、LDL、发病时收缩压、血清hs-CRP 和血清Hcy。血清Hcy浓度升高可能为中青年进展性卒中患者的独立危险因素。
목적：분석중청년진전성뇌졸중환자적위험인소。방법근거병정，장동시기29～60세급성결혈성뇌졸중환자140례，위저분자간소급성졸중시험（ TOAST）분형대、소혈관병변형，분위진전성졸중조70례，즉연구조；완전성졸중환자70례，즉대조조。비교연구조화대조조적일반자료、생물화학지표급두로영상학적불동。결과고혈압병사、기주사、입원시소측수축압、대혈관병변、저밀도지단백、초민C반응단백（hs-CRP）급동형반광안산（Hcy）농도량조간비교차이유통계학의의（P＜0．05，P＜0．01）；다원축보회귀분석발현혈청Hcy농도、hs-CRP농도급LDL정상관。결론중청년환자진전성졸중적위험인소위고혈압병사、기주사、대혈관병변、LDL、발병시수축압、혈청hs-CRP 화혈청Hcy。혈청Hcy농도승고가능위중청년진전성졸중환자적독립위험인소。
Objective To analysis risk factors for patients in young and middle-aged with progressive stroke (PS).Methods 140 patients (aged 29~60years) with acute ischemic strok were classified into large-artery atherosclerosis and small-vessel occlusion based on TOAST .Divide patients with acute ischemic stroke at the same stage into research group ( 70 patients with PS ) and control group ( 70 patients with completed ischemic stroke ) according to the progression of patients .Compare to seek differences between the two groups via statistical analysis of physical data , biochemical indexes and head images .Results There are statistically significant differences in history of hypertension , alcoholism , increases of systolic blood pressure upon admission , macro vascular diseases , low density lipoprotein ( LDL ) concentrations of high-sensitive C-reactive protein ( hs-CRP ) and serum homocysteine (Hcy) between the two groups (P<0.01 or P<0.05).Multiple stepwise regression analysis showed the concentration of serum Hcy was positively related with LDL and the concentration of hs-CRP .Conclusion Risk factors of patients with PS include history of hypertension , alcoholism, large-artery atherosclerosis , LDL and the increases of systolic blood pressure , concentration of hs-CRP and serum Hcy when the disease attacking .The increase of serum Hcy is a possible independent risk factor of young and middle-aged patients with PS .