CAJ | 학술논문

目的：观察硫辛酸胶囊治疗缓解期多发性硬化（ MS）及视神经脊髓炎（ NMO）的临床疗效。方法2012年7月至2013年10月就诊于我院的符合MS与NMO诊断标准的16例缓前期患者，按患者病程长短分为1年、1年以上两组，均给予口服硫辛酸胶囊0．6· d -1治疗，于患者治疗前和治疗后1个月及3个月分别采用扩充神经功能残疾量表（ EDSS ）方法评价患者日常生活能力。结果硫辛酸胶囊治疗后，两组患者治疗前后EDSS评分比较，p＜0．05；并且短病程组患者的EDSS评分改善显著好于长病程组，两组间比较，p＜0．05虽然两组患者口服3个月比口服1个月时的EDSS评分仍有改善，差异无统计学意义（ p＞0．05）。结论硫辛酸胶囊可显著降低患者神经功能残疾程度，并且越早服用硫辛酸治疗效果越好；随着服用时间延长，其益处可能更加明显。该药物副反应轻微，效果良好，为中枢神经脱髓鞘病缓解期的治疗提供了一种新的选择。
목적：관찰류신산효낭치료완해기다발성경화（ MS）급시신경척수염（ NMO）적림상료효。방법2012년7월지2013년10월취진우아원적부합MS여NMO진단표준적16례완전기환자，안환자병정장단분위1년、1년이상량조，균급여구복류신산효낭0．6· d -1치료，우환자치료전화치료후1개월급3개월분별채용확충신경공능잔질량표（ EDSS ）방법평개환자일상생활능력。결과류신산효낭치료후，량조환자치료전후EDSS평분비교，p＜0．05；병차단병정조환자적EDSS평분개선현저호우장병정조，량조간비교，p＜0．05수연량조환자구복3개월비구복1개월시적EDSS평분잉유개선，차이무통계학의의（ p＞0．05）。결론류신산효낭가현저강저환자신경공능잔질정도，병차월조복용류신산치료효과월호；수착복용시간연장，기익처가능경가명현。해약물부반응경미，효과량호，위중추신경탈수초병완해기적치료제공료일충신적선택。
Objective TO observe the clinical effects of lipoic acid capsules for remission patients with multiple sclerosis and neuromyelitis opticaM.ethods Sixteen patients according to diagnostic criteria were treated between July 2012 to October2013 in our hospital ,and divided into two groups according to the courses of disease -1 year and1year over , the both group patients were given lipoic acid capsule with 0.6g.d -1.The patients before treatment and one month 、three months after treatment were evaluated with adopt expansion of expanded disability status scale(EDSS) method to evaluate patients'daily life ability.Results After take the lipoic acid treatment, the EDSS score of the two groups of patients have significant reduced;And the short course group of patients with EDSS score reduced obviously better than the long course of group , there are distinct differences between the two groups (p<0.05).In addition,the EDSS score difference of two groups of patients still be improved in 1 month and 3 months,but there is no significant change in EDSS score difference in different months (p>0.05).Conclusion Oral lipoic acid capsule can significantly reduce the degree of neural function disability in patients , and the earlier taking lipoic acid treatment, the better treatment results; And with taking the time longer , the benefits may be more apparent ;The drug with slightly side effects and good effect ,maybe an efficiently drug for remission of demyelinating diseases .