CAJ | 학술논문

目的：探讨不同部位重型脑梗死（脑干梗死、半球大面积梗死）患者肠黏膜屏障变化。方法选取重型脑梗死患者共56例，（脑干梗死22例，半球大面积梗死34例），分别于患病后24h、72h、1w及2w采集空腹静脉血，同时选取同期门诊健康体检者30例作为对照，抽取空腹静脉血，采用双抗体夹心ELISA法测定血清二胺氧化酶（ DAO）、D-乳酸（ D-LAC）检测含量。结果无论半球大面积梗死还是脑干梗死，患者在患病后很快出现肠黏膜屏障功能的改变，在患病24h达较高水平，随后的72h、1w及2w血清D-LAC及DAO持续高水平，2组患者于2w后呈降低趋势，但仍高于对照组。结论无论半球大面积脑梗死还是脑干梗死，患者患病后24h内即可出现黏膜屏障功能损伤，2组患者肠黏膜屏障功能损伤可持续2w或更长时间。
목적：탐토불동부위중형뇌경사（뇌간경사、반구대면적경사）환자장점막병장변화。방법선취중형뇌경사환자공56례，（뇌간경사22례，반구대면적경사34례），분별우환병후24h、72h、1w급2w채집공복정맥혈，동시선취동기문진건강체검자30례작위대조，추취공복정맥혈，채용쌍항체협심ELISA법측정혈청이알양화매（ DAO）、D-유산（ D-LAC）검측함량。결과무론반구대면적경사환시뇌간경사，환자재환병후흔쾌출현장점막병장공능적개변，재환병24h체교고수평，수후적72h、1w급2w혈청D-LAC급DAO지속고수평，2조환자우2w후정강저추세，단잉고우대조조。결론무론반구대면적뇌경사환시뇌간경사，환자환병후24h내즉가출현점막병장공능손상，2조환자장점막병장공능손상가지속2w혹경장시간。
Objective To study the changes of intestinal mucosal barrier in patients with different area severe cerebral infarction ( brain stem infarction , hemisphere infarction ) .Methods 56 patients with different area severe cerebral infarction ( 22 was brain stem infarction and 34 was hemisphere severe cerebral infarction ) , respectively in 24h, 72h,1w ,2w after the illness, venous blood was collected , and 30 healthy subjects served as control.The serum diamine oxidase (DAO)and D-lactic acid (D-LAC) were detected in 56 patients and 30 normal controls by double antibody enzyme linked immunosorbent assay .Results Whether hemispheric infarction or brain stem infarction, patients with intestinal mucosal barrier function changes soon after illness sickness , in 24 hours,72 hours, 1 week and 2 weeks serum D-LAC and DAO levels remain high,lasted a higher level.The two groups patients showed decreasing trend after 2 weeks, but still higher than that of the control group .Conclusion Hemisphere severe infarction and brain stem infarction patients can appear mucous membrane barrier function damage after illness in 24 hours, and the damage can last 2 weeks or longer .