CAJ | 학술논문

目的：观察α-硫辛酸（α-LA）对多发性硬化（ MS）认知障碍的疗效，探讨α-LA对MS的可能治疗机制。方法收集30例MS患者和30例健康体检者，采用神经心理学测试的方法评价患者治疗前的认知功能；MS组患者根据治疗情况分为两组，MS对照组，给予激素冲击治疗；α-LA治疗组，给予激素冲击和硫辛酸联合治疗。治疗后继续应用神经心理学测试的方法评价患者认知功能；比较治疗前后的认知功能改善情况。结果临床功能障碍评价表明MS患者存在明显的认知功能下降（ P＜0．05），治疗后MS对照组认知功能改善无明显变化（ P＞0．05），α-LA治疗组认知功能改善明显（ P＜0．05）。结论α-LA通过多种作用机制对MS具有保护作用，能明显改善患者认知功能。
목적：관찰α-류신산（α-LA）대다발성경화（ MS）인지장애적료효，탐토α-LA대MS적가능치료궤제。방법수집30례MS환자화30례건강체검자，채용신경심이학측시적방법평개환자치료전적인지공능；MS조환자근거치료정황분위량조，MS대조조，급여격소충격치료；α-LA치료조，급여격소충격화류신산연합치료。치료후계속응용신경심이학측시적방법평개환자인지공능；비교치료전후적인지공능개선정황。결과림상공능장애평개표명MS환자존재명현적인지공능하강（ P＜0．05），치료후MS대조조인지공능개선무명현변화（ P＞0．05），α-LA치료조인지공능개선명현（ P＜0．05）。결론α-LA통과다충작용궤제대MS구유보호작용，능명현개선환자인지공능。
Objective This study is to understand the efficacy of alpha lipoic acid (α-LA) with multiple sclerosis(MS), and investigate the possible therapeutic mechanism .Methods Thirty patients with MS and thirty healthy patients were involved in the study .The neuropsychological test was used to assess the patient 's cognitive function.According the treatment, the patients with MS were divided into two groups , MS control group was given hormone, andα-LA treatment group was given hormone and α-LA.The neuropsychological test was used to assess the patient's cognitive function after treatment , and assess improvement of cognitive function .Results The patients with multiple sclerosis had significant decline in general cognitive function ( P<0.05) , MS control group had no significant improvement (P>0.05), α-LA treatment group had significant improvement (P<0.05).Conclusion α-LA can protect MS through a variety of mechanisms , and can significantly improve cognitive function .