化学分析计量
化學分析計量
화학분석계량
CHEMICAL ANALYSIS AND METERAGE
2014年
3期
9-13
,共5页
周严严%赵睁睁%郭小藤%容蓉%吕青涛%巩丽丽%杨勇
週嚴嚴%趙睜睜%郭小籐%容蓉%呂青濤%鞏麗麗%楊勇
주엄엄%조정정%곽소등%용용%려청도%공려려%양용
芎汤%活血有效部位%HPLC指纹图谱%排泄规律%欧氏距离
芎湯%活血有效部位%HPLC指紋圖譜%排洩規律%歐氏距離
궁탕%활혈유효부위%HPLC지문도보%배설규률%구씨거리
Xiongqiong decoction%blood activating fraction%HPLC fingerprint%excretion pattern%euclidean distance
利用HPLC指纹图谱研究大鼠灌服芎汤活血有效部位前后尿和粪便样品,并计算特征峰欧式距离,考察粪、尿中药物多成分累积排泄的总体变化趋势。将芎汤有效部位给SD大鼠灌胃后,总体成分在尿样中于8~12 h达到排泄高峰,在粪样中于12~24 h达到排泄高峰。采用指纹图谱技术测定排泄物中多成分的排泄曲线,可以更好地阐明中药复方排泄规律。
利用HPLC指紋圖譜研究大鼠灌服芎湯活血有效部位前後尿和糞便樣品,併計算特徵峰歐式距離,攷察糞、尿中藥物多成分纍積排洩的總體變化趨勢。將芎湯有效部位給SD大鼠灌胃後,總體成分在尿樣中于8~12 h達到排洩高峰,在糞樣中于12~24 h達到排洩高峰。採用指紋圖譜技術測定排洩物中多成分的排洩麯線,可以更好地闡明中藥複方排洩規律。
이용HPLC지문도보연구대서관복궁탕활혈유효부위전후뇨화분편양품,병계산특정봉구식거리,고찰분、뇨중약물다성분루적배설적총체변화추세。장궁탕유효부위급SD대서관위후,총체성분재뇨양중우8~12 h체도배설고봉,재분양중우12~24 h체도배설고봉。채용지문도보기술측정배설물중다성분적배설곡선,가이경호지천명중약복방배설규률。
It was studied that the urinary and fecal excretion of blood activating fraction of Xiongqiong decoction before and after oral administration in rats by HPLC fingerprint. The euclidean distance was calculated according to the characteristic peak area of HPLC fingerprint and used as the integral index for the cumulative excretion trends of multi-components in Xiongqiong decoction. The overall excretion of multiple composition in urine and faeces reached a peak in 8-12 h and 12-24 h, respectively. Integral fingerprint is proposed to be an ideal method which could be used to study the excretion pattern of traditional Chinese medicine formula.