CAJ | 학술논문

目的：探讨宫颈鳞癌组织中胸苷酸合成酶（ TS）和DNA拓扑异构酶Ⅱα（ TopoⅡα）的表达与新辅助化疗效果的关系。方法：采用免疫组化SP法检测54例宫颈鳞癌患者宫颈组织中TS、TopoⅡα的表达。结果：54例宫颈鳞癌患者中34例对NACT有反应，总有效率为72．2％，无效率为27．8％。宫颈癌患者组织中TS、TopoⅡα的表达水平与NACT疗效有关（χ2＝7．020和9．026，P＜0．05）。 TS低表达者的化疗有效率高于高表达者，TopoⅡα高表达者的化疗有效率高于低表达者。结论：TS低表达和TopoⅡα高表达的患者均可从NACT中获益，两者是否可以作为宫颈癌患者NACT疗效指标值得进一步研究。
목적：탐토궁경린암조직중흉감산합성매（ TS）화DNA탁복이구매Ⅱα（ TopoⅡα）적표체여신보조화료효과적관계。방법：채용면역조화SP법검측54례궁경린암환자궁경조직중TS、TopoⅡα적표체。결과：54례궁경린암환자중34례대NACT유반응，총유효솔위72．2％，무효솔위27．8％。궁경암환자조직중TS、TopoⅡα적표체수평여NACT료효유관（χ2＝7．020화9．026，P＜0．05）。 TS저표체자적화료유효솔고우고표체자，TopoⅡα고표체자적화료유효솔고우저표체자。결론：TS저표체화TopoⅡα고표체적환자균가종NACT중획익，량자시부가이작위궁경암환자NACT료효지표치득진일보연구。
Aim:To explore relationship between the expressions of TS and TopoⅡαin cervical squamous cancer tis-sue and the efficacy of neoadjuvant chemotherapy ( NACT) of taxol and carbon ( TC) .Methods:TS and TopoⅡαexpres-sions in 54 specimens of cervical squamous cancer were detected by SP immunohistochemistry .Results:34 out of 54 cer-vical squamous cancer patients reacted to NACT , and the total effective rate was 72.2%, ineffective rate was 27.8%. There was correlation between TS,TopoⅡαexpressions and the curative effect of NACT (χ2 =7.020 and 9.026,P<0.05).Conclusion:The patients with lower expression of TS and higher expression of Topo Ⅱαcan benefit from NACT, and whether TS and TopoⅡαcan serve as factors for chemotherapy efficacy in cervical squamous cancer is worthy of further research.