郑州大学学报(医学版)
鄭州大學學報(醫學版)
정주대학학보(의학판)
JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES)
2014年
3期
397-400
,共4页
孙利强%陈杰%李恩%刘宗芳%张丽华%简立国
孫利彊%陳傑%李恩%劉宗芳%張麗華%簡立國
손리강%진걸%리은%류종방%장려화%간입국
半乳糖凝集素-3%C反应蛋白%急性冠脉综合征
半乳糖凝集素-3%C反應蛋白%急性冠脈綜閤徵
반유당응집소-3%C반응단백%급성관맥종합정
Galectin-3%C-reactive protein%acute coronary syndrome
目的:观察急性冠脉综合征患者的血清半乳糖凝集素-3(Galectin-3)与C反应蛋白(CRP)的变化,并探讨其临床意义。方法:188例冠心病患者分为急性心肌梗死组( AMI组)52例、不稳定型心绞痛组( UAP组)76例、稳定型心绞痛组( SAP组)60例,另选同期59例健康者作为对照组。检测各组血清中Galectin-3和CRP的水平。结果:与对照组[(4.4±1.6)μg/L、(5.5±2.7) mg/L]和SAP组[(5.0±2.2)μg/L、(6.7±2.9) mg/L]相比,AMI组[(9.79±3.24)μg/L、(25.8±10.9) mg/L]和UAP组[(7.7±3.1)μg/L、(21.3±9.2) mg/L]血清Galectin-3、CRP水平均明显升高(F=12.439和16.649,P<0.001),且AMI 组高于UAP组(P<0.05),对照组与SAP组之间差异无统计学意义(P>0.05)。结论:血清中Galectin-3和CRP与急性冠脉综合征临床事件的严重程度密切相关,可作为该类患者危险分层的参考指标。
目的:觀察急性冠脈綜閤徵患者的血清半乳糖凝集素-3(Galectin-3)與C反應蛋白(CRP)的變化,併探討其臨床意義。方法:188例冠心病患者分為急性心肌梗死組( AMI組)52例、不穩定型心絞痛組( UAP組)76例、穩定型心絞痛組( SAP組)60例,另選同期59例健康者作為對照組。檢測各組血清中Galectin-3和CRP的水平。結果:與對照組[(4.4±1.6)μg/L、(5.5±2.7) mg/L]和SAP組[(5.0±2.2)μg/L、(6.7±2.9) mg/L]相比,AMI組[(9.79±3.24)μg/L、(25.8±10.9) mg/L]和UAP組[(7.7±3.1)μg/L、(21.3±9.2) mg/L]血清Galectin-3、CRP水平均明顯升高(F=12.439和16.649,P<0.001),且AMI 組高于UAP組(P<0.05),對照組與SAP組之間差異無統計學意義(P>0.05)。結論:血清中Galectin-3和CRP與急性冠脈綜閤徵臨床事件的嚴重程度密切相關,可作為該類患者危險分層的參攷指標。
목적:관찰급성관맥종합정환자적혈청반유당응집소-3(Galectin-3)여C반응단백(CRP)적변화,병탐토기림상의의。방법:188례관심병환자분위급성심기경사조( AMI조)52례、불은정형심교통조( UAP조)76례、은정형심교통조( SAP조)60례,령선동기59례건강자작위대조조。검측각조혈청중Galectin-3화CRP적수평。결과:여대조조[(4.4±1.6)μg/L、(5.5±2.7) mg/L]화SAP조[(5.0±2.2)μg/L、(6.7±2.9) mg/L]상비,AMI조[(9.79±3.24)μg/L、(25.8±10.9) mg/L]화UAP조[(7.7±3.1)μg/L、(21.3±9.2) mg/L]혈청Galectin-3、CRP수평균명현승고(F=12.439화16.649,P<0.001),차AMI 조고우UAP조(P<0.05),대조조여SAP조지간차이무통계학의의(P>0.05)。결론:혈청중Galectin-3화CRP여급성관맥종합정림상사건적엄중정도밀절상관,가작위해류환자위험분층적삼고지표。
Aim:To determine the serum levels of Galectin-3 and C-reactive protein(CRP) in patients with acute cor-onary syndrome(ACS).Methods:A total of 188 patients with coronary heart disease (CHD) were enrolled in this study and 59 healthy persons were selected as control .Clinical phenotypes of CHD included acute myocardial infarction ( AMI) , unstable angina pectoris ( UAP) and stable angina pectoris ( SAP) .Serum levels of Galectin-3 and CRP were determined at 12 hours after the appearance of symptoms in AMI or on admission in other groups .Results: Compared with SAP group [(5.0 ±2.2) μg/L, (6.7 ±2.9) mg/L] and the control group[(4.4 ±1.6) μg/L, (5.5 ±2.7) mg/L], the levels of serum Galectin-3 and CRP were significantly higher in AMI group [(9.79 ±3.24) μg/L, (25.8 ±10.9) mg/L ]and UAP group[(7.7 ±3.1) μg/L, (21.3 ±9.2) mg/L](F=12.439 and 16.649,P<0.001);the levels of Galectin-3 and CRP were significantly higher in AMI group than those in UAP group (P<0.05).There was no difference between SAP group and the control group(P>0.05).Conclusion:The serum levels of Galectin-3 and CRP are highly related to the severity of clinical events in patients with ACS , which might be used as reference markers for risk stratification in patients with ACS.