CAJ | 학술논문

目的：探讨高血压晨峰（MBPS）对脂蛋白相关磷脂酶A2（Lp-PLA2）与冠状动脉钙化积分（CACS）的影响。方法：高血压患者208例，根据24 h动态血压监测结果分为MBPS组110例和非MBPS组98例，ELISA法检测血清Lp-PLA2水平，多层螺旋CT评价CACS。结果：MBPS组患者的Lp-PLA2水平明显高于非MBPS组（t＝2．635， P＝0．011）；MBPS组患者的左前降支（LAD）、左回旋支（LCX）、左冠状动脉主支（LM）的钙化积分明显高于非MB-PS组（t＝2．361、2．183、2．062，P均＜0．05）。结论：MBPS可能激活高血压患者心血管系统的炎症反应，并使冠状动脉钙化加重。
목적：탐토고혈압신봉（MBPS）대지단백상관린지매A2（Lp-PLA2）여관상동맥개화적분（CACS）적영향。방법：고혈압환자208례，근거24 h동태혈압감측결과분위MBPS조110례화비MBPS조98례，ELISA법검측혈청Lp-PLA2수평，다층라선CT평개CACS。결과：MBPS조환자적Lp-PLA2수평명현고우비MBPS조（t＝2．635， P＝0．011）；MBPS조환자적좌전강지（LAD）、좌회선지（LCX）、좌관상동맥주지（LM）적개화적분명현고우비MB-PS조（t＝2．361、2．183、2．062，P균＜0．05）。결론：MBPS가능격활고혈압환자심혈관계통적염증반응，병사관상동맥개화가중。
Aim:To analyse the effects of hypertensive morning peak ( MBPS) phenomenon on lipoprotein-associated phospholipase A2(Lp-PLA2) and coronary artery calcification score (CACS).Methods:A total of 208 cases of hyperten-sion under 24 h ambulatory blood pressure monitoring were divided into MBPS group (110 cases) and non-MBPS group (98 cases).Lp-PLA2 was detected by ELISA method .CACS was evaluated through multislice spiral CT .Results:The level of Lp-PLA2 in MBPS group was higher than that in non-MBPS group(t=2.635,P=0.011);the CACS of LAD, LCX, and LM in MBPS group were higher than those in non-MBPS group(t=2.361,2.183,2.062,P<0.05).Conclusion:MBPS can activate inflammatory response in cardiovascular system and increase coronary artery calcfication in patients with hyper -tension.