CAJ | 학술논문

目的：分析河南地区肿瘤、慢性丙型肝炎、白癜风患者HLA-A2的分布频率。方法：应用流式细胞术和聚合酶链反应/序列特异性引物（ PCR-SSP）技术检测分析了72例健康人（正常对照）和438例肿瘤患者、110例慢性丙型肝炎患者、97例白癜风患者外周血中HLA-A2抗原的分布频率。结果：肿瘤、慢性丙型肝炎、白癜风患者中HLA-A2抗原的分布频率分别为49．1％、39．0％、47．4％，与正常对照组的48．6％比较，差异均无统计学意义（χ2＝0．006，1．611，0．230，P均＞0．05）。病例数超过50的肺癌（91例）、胃癌（56例）和食管癌（126例）患者中HLA-A2分布频率分别为42．9％、57．1％和38．0％，与正常对照比较，差异亦无统计学意义（χ2＝0．537，0．919，2．081，P均＞0．05）。结论：河南肿瘤、慢性丙型肝炎及白癜风患者HLA-A2的分布无特异性，因此HLA-A2限制性的生物细胞免疫治疗具有广泛的应用价值。
목적：분석하남지구종류、만성병형간염、백전풍환자HLA-A2적분포빈솔。방법：응용류식세포술화취합매련반응/서렬특이성인물（ PCR-SSP）기술검측분석료72례건강인（정상대조）화438례종류환자、110례만성병형간염환자、97례백전풍환자외주혈중HLA-A2항원적분포빈솔。결과：종류、만성병형간염、백전풍환자중HLA-A2항원적분포빈솔분별위49．1％、39．0％、47．4％，여정상대조조적48．6％비교，차이균무통계학의의（χ2＝0．006，1．611，0．230，P균＞0．05）。병례수초과50적폐암（91례）、위암（56례）화식관암（126례）환자중HLA-A2분포빈솔분별위42．9％、57．1％화38．0％，여정상대조비교，차이역무통계학의의（χ2＝0．537，0．919，2．081，P균＞0．05）。결론：하남종류、만성병형간염급백전풍환자HLA-A2적분포무특이성，인차HLA-A2한제성적생물세포면역치료구유엄범적응용개치。
Aim:To investigate HLA-A2 frequencies in the patients either with cancer or chronic hepatitis C , or vitili-go in Henan Province .Methods:The frequencies of HLA-A2 in 72 healthy people , 438 patients with tumors , 110 patients with chronic hepatitis C , and 97 patients with vitiligo , were detected by flow cytometry and PCR sequence specific primer (PCR-SSP).Results:The frequencies of HLA-A2 in patients with tumors, chronic hepatitis C, and vitiligo were 49.1%, 39.0%, and 47.4%,respectively,which had no significant differences from that of 48.6% in the healthy people (χ2 =0.006,1.611,0.230,P>0.05).The frequencies of HLA-A2 in patients with lung cancer(91 cases), gastric cancer(56 cases),and esophageal cancer (126 cases) were 42.9%,57.1%and 38.0%,which had no significant differences from that of the healthy people(χ2 =0.537,0.919,2.081,P>0.05).Conclusion:HLA-A2 is widely expressed in Henan popula-tion and it is valuable of applying HLA-A2 restricted immunotherapy for Henan population .