郑州大学学报(医学版)
鄭州大學學報(醫學版)
정주대학학보(의학판)
JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES)
2014年
3期
323-326
,共4页
冯悦静%魏小玲%尤爱国%周安燕%吴拥军%王威%何其栋%王静
馮悅靜%魏小玲%尤愛國%週安燕%吳擁軍%王威%何其棟%王靜
풍열정%위소령%우애국%주안연%오옹군%왕위%하기동%왕정
肺,肿瘤%DNA甲基化转移酶%组蛋白去乙酰化酶1
肺,腫瘤%DNA甲基化轉移酶%組蛋白去乙酰化酶1
폐,종류%DNA갑기화전이매%조단백거을선화매1
lung,neoplasm%DNA methyltransferase%histone deacetylases 1
目的:研究肺癌患者血清中DNA甲基化转移酶(DNMT)1、DNMT3a、DNMT3b和组蛋白去乙酰化酶1(HDAC1)蛋白的表达情况。方法:采用酶联免疫吸附试验(ELISA)方法测定136例肺癌患者、140例肺良性疾病及145例健康体检者血清中DNMT1、DNMT3a、DNMT3b和HDAC1蛋白的表达,并分析DNMT1、DNMT3a、DNMT3b和HDAC1蛋白表达与肺癌临床病理特征的关系。结果:3组血清中DNMT1、DNMT3a、DNMT3b和HDAC1蛋白表达差异有统计学意义( F=3.281、62.510、37.273、57.721,P<0.05),肺癌患者均高于正常对照及肺良性疾病患者;非条件logistic回归分析提示DNMT1、DNMT3a、DNMT3b和HDAC1蛋白高表达均可影响肺癌的发生发展(P<0.001);肺癌患者血清中DNMT1、DNMT 3a、DNMT 3b和HDAC1蛋白表达无组织学类型特异性(P>0.05),但不同临床分期其蛋白表达差异有统计学意义(t=0.843、0.244、0.222、0.878,P<0.05)。结论:肺癌患者血清中DNMT1、DN-MT3a、DNMT3b和HDAC1蛋白的高表达可能在肺癌的发生发展中发挥一定的作用。
目的:研究肺癌患者血清中DNA甲基化轉移酶(DNMT)1、DNMT3a、DNMT3b和組蛋白去乙酰化酶1(HDAC1)蛋白的錶達情況。方法:採用酶聯免疫吸附試驗(ELISA)方法測定136例肺癌患者、140例肺良性疾病及145例健康體檢者血清中DNMT1、DNMT3a、DNMT3b和HDAC1蛋白的錶達,併分析DNMT1、DNMT3a、DNMT3b和HDAC1蛋白錶達與肺癌臨床病理特徵的關繫。結果:3組血清中DNMT1、DNMT3a、DNMT3b和HDAC1蛋白錶達差異有統計學意義( F=3.281、62.510、37.273、57.721,P<0.05),肺癌患者均高于正常對照及肺良性疾病患者;非條件logistic迴歸分析提示DNMT1、DNMT3a、DNMT3b和HDAC1蛋白高錶達均可影響肺癌的髮生髮展(P<0.001);肺癌患者血清中DNMT1、DNMT 3a、DNMT 3b和HDAC1蛋白錶達無組織學類型特異性(P>0.05),但不同臨床分期其蛋白錶達差異有統計學意義(t=0.843、0.244、0.222、0.878,P<0.05)。結論:肺癌患者血清中DNMT1、DN-MT3a、DNMT3b和HDAC1蛋白的高錶達可能在肺癌的髮生髮展中髮揮一定的作用。
목적:연구폐암환자혈청중DNA갑기화전이매(DNMT)1、DNMT3a、DNMT3b화조단백거을선화매1(HDAC1)단백적표체정황。방법:채용매련면역흡부시험(ELISA)방법측정136례폐암환자、140례폐량성질병급145례건강체검자혈청중DNMT1、DNMT3a、DNMT3b화HDAC1단백적표체,병분석DNMT1、DNMT3a、DNMT3b화HDAC1단백표체여폐암림상병리특정적관계。결과:3조혈청중DNMT1、DNMT3a、DNMT3b화HDAC1단백표체차이유통계학의의( F=3.281、62.510、37.273、57.721,P<0.05),폐암환자균고우정상대조급폐량성질병환자;비조건logistic회귀분석제시DNMT1、DNMT3a、DNMT3b화HDAC1단백고표체균가영향폐암적발생발전(P<0.001);폐암환자혈청중DNMT1、DNMT 3a、DNMT 3b화HDAC1단백표체무조직학류형특이성(P>0.05),단불동림상분기기단백표체차이유통계학의의(t=0.843、0.244、0.222、0.878,P<0.05)。결론:폐암환자혈청중DNMT1、DN-MT3a、DNMT3b화HDAC1단백적고표체가능재폐암적발생발전중발휘일정적작용。
Aim:To study the expressions of DNMT1, DNMT3a, DNMT3b and HDAC1 in serum from patients with lung cancer.Methods:ELISA was used to measure the expressions of DNMT1, DNMT3a, DNMT3b and HDAC1 in the serum from 136 lung cancer patients ,140 cases of lung benign diseases and 145 healthy people ( control group ) , and the relationship between the expressions of DNMT 1, DNMT3a, DNMT3b, HDAC1 and clinical characteristics of lung cancer was analyzed.Results:The expressions of DNMT1, DNMT3a, DNMT3b and HDAC1 in patients with lung cancer were higher than those in lung benign diseases group and control group (F=3.281,62.510,37.273,57.721,P<0.05).The re-sult of logistic regression showed that the overexpressions of DNMT 1, DNMT3a,DNMT3b and HDAC1 might increase the risk of lung cancer (P<0.001).There were no correlations among the expressions of DNMT 1, DNMT3a, DNMT3b or HDAC1 between different histological types (P>0.05),while there were statistical significances in the expressions of DNMT 1, DN-MT3a, DNMT3b and HDAC1 between different stages (t=0.843,0.244,0.222,0.878,P<0.05).Conclusion:The overex-pressions of DNMT1, DNMT3a, DNMT3b and HDAC1 could contribute to the occurrence and development of lung cancer .