CAJ | 학술논문

CXC型趋化因子受体4（CXCR4）及CXC型趋化因子配体12（CXCL12）在肿瘤生长、新生血管形成和远处转移等方面发挥了至关重要的作用。两者结合后可以激活下游信号通路，从而发挥促进肿瘤生长和血管生成的作用。肿瘤组织高表达CXCR4，而肿瘤较常发生转移的部位高表达CXCL12，两者之间可通过特异性的结合而促使肿瘤发生转移。因此，CXCR4的表达水平在肿瘤转移的诊断方面具有预示性的作用，而无创性的影像学诊断方法，如SPECT/CT、PET显像等，有望在CXCR4的显像方面发挥重要作用，从而实现肿瘤的早期诊断和早期治疗。
CXC형추화인자수체4（CXCR4）급CXC형추화인자배체12（CXCL12）재종류생장、신생혈관형성화원처전이등방면발휘료지관중요적작용。량자결합후가이격활하유신호통로，종이발휘촉진종류생장화혈관생성적작용。종류조직고표체CXCR4，이종류교상발생전이적부위고표체CXCL12，량자지간가통과특이성적결합이촉사종류발생전이。인차，CXCR4적표체수평재종류전이적진단방면구유예시성적작용，이무창성적영상학진단방법，여SPECT/CT、PET현상등，유망재CXCR4적현상방면발휘중요작용，종이실현종류적조기진단화조기치료。
CXC chemokine receptor type 4 (CXCR4) and its ligand (CXCL12) exerts crucial influence in regulating tumor growth, angiogenesis and metastasis. Studies show that the downstream sig-naling pathway can be activated by interaction of the chemokine receptor and its ligand to promote tumor growth and angiogenesis. Additional observation suggests that neoplastic tissue expresses high levels of CXCR4, and the site of tumor metastasis over expresses CXCL12, through which this specific binding abil-ity can induce tumor metastasis. Thus, the CXCR4 levels could be used as a predictive marker of metastat-ic potential. Hopefully, the non-invasive imaging methods, such as SPECT/CT, PET, are employed in the imaging of the chemokine receptors to diagnose and treat the tumors in the early stage.