国际放射医学核医学杂志
國際放射醫學覈醫學雜誌
국제방사의학핵의학잡지
INTERNATIONAL JOURNAL OF RADIATION MEDICINE AND NUCLEAR MEDICINE
2014年
3期
167-170
,共4页
冠心病%血管紧张素Ⅱ%神经肽Y%胰岛素样生长因子-Ⅰ%高敏C-反应蛋白%放射免疫测定%免疫酶技术
冠心病%血管緊張素Ⅱ%神經肽Y%胰島素樣生長因子-Ⅰ%高敏C-反應蛋白%放射免疫測定%免疫酶技術
관심병%혈관긴장소Ⅱ%신경태Y%이도소양생장인자-Ⅰ%고민C-반응단백%방사면역측정%면역매기술
Coronary heart disease%AngiotensinⅡ%Neuropepti-de Y%Insulin-like growth factorⅠ%High sensitive C-reaction protein%Radioimmunoassay%Immunoenzyme techniques
目的：探讨血浆血管紧张素Ⅱ（ATⅡ）、神经肽Y（NPY）、胰岛素样生长因子1（IGF-1）和高敏C反应蛋白（hs-CRP）水平测定在评估冠心病患者严重程度中的应用价值。方法采用放射免疫分析、酶免疫分析和高敏酶免疫分析法分别测定157例冠心病患者[包括51例稳定型心绞痛（SA）患者、45例不稳定型心绞痛（USA）患者和61例急性心肌梗死（AMI）患者]的血浆ATⅡ、NPY、IGF-1和hs-CRP水平，并与60名正常对照者进行对比分析。结果157例CHD患者血浆ATⅡ水平与60名正常对照者相比，差异有统计学意义（tSA ATⅡ=2．257，P＜0．05；tUSA ATⅡ=3．018，P＜0．01；tAMI ATⅡ=4．143，P＜0．001）；血浆NPY水平较正常对照者增高（tSA NPY=1．413，P＞0．05；tUSA NPY=2．148，P＜0．05；tAMI NPY=3．068，P＜0．01），但SA患者与正常对照者之间的差异无统计学意义；血浆IGF-1水平与正常对照者相比，差异有统计学意义（tSA IGF-1=2．121，P＜0．05；tUSA IGF-1=2．937，P＜0．01；tAMIIGF-1=4．217，P＜0．001）；血浆hs-CRP水平与正常对照者相比，差异有统计学意义（tSAhs-CRP=2．095，P＜0．05；tUSA hs-CRP=2．867，P＜0．01；tAMI hs-CRP=4．349，P＜0．001）。血浆ATⅡ、NPY、IGF-1和hs-CRP水平随着SA、USA和AMI患者的严重程度而增高。结论血浆ATⅡ、NPY、IGF-1和hs-CRP水平是判断冠心病患者严重程度的有价值指标，亦可以用于治疗后的随访。
目的：探討血漿血管緊張素Ⅱ（ATⅡ）、神經肽Y（NPY）、胰島素樣生長因子1（IGF-1）和高敏C反應蛋白（hs-CRP）水平測定在評估冠心病患者嚴重程度中的應用價值。方法採用放射免疫分析、酶免疫分析和高敏酶免疫分析法分彆測定157例冠心病患者[包括51例穩定型心絞痛（SA）患者、45例不穩定型心絞痛（USA）患者和61例急性心肌梗死（AMI）患者]的血漿ATⅡ、NPY、IGF-1和hs-CRP水平，併與60名正常對照者進行對比分析。結果157例CHD患者血漿ATⅡ水平與60名正常對照者相比，差異有統計學意義（tSA ATⅡ=2．257，P＜0．05；tUSA ATⅡ=3．018，P＜0．01；tAMI ATⅡ=4．143，P＜0．001）；血漿NPY水平較正常對照者增高（tSA NPY=1．413，P＞0．05；tUSA NPY=2．148，P＜0．05；tAMI NPY=3．068，P＜0．01），但SA患者與正常對照者之間的差異無統計學意義；血漿IGF-1水平與正常對照者相比，差異有統計學意義（tSA IGF-1=2．121，P＜0．05；tUSA IGF-1=2．937，P＜0．01；tAMIIGF-1=4．217，P＜0．001）；血漿hs-CRP水平與正常對照者相比，差異有統計學意義（tSAhs-CRP=2．095，P＜0．05；tUSA hs-CRP=2．867，P＜0．01；tAMI hs-CRP=4．349，P＜0．001）。血漿ATⅡ、NPY、IGF-1和hs-CRP水平隨著SA、USA和AMI患者的嚴重程度而增高。結論血漿ATⅡ、NPY、IGF-1和hs-CRP水平是判斷冠心病患者嚴重程度的有價值指標，亦可以用于治療後的隨訪。
목적：탐토혈장혈관긴장소Ⅱ（ATⅡ）、신경태Y（NPY）、이도소양생장인자1（IGF-1）화고민C반응단백（hs-CRP）수평측정재평고관심병환자엄중정도중적응용개치。방법채용방사면역분석、매면역분석화고민매면역분석법분별측정157례관심병환자[포괄51례은정형심교통（SA）환자、45례불은정형심교통（USA）환자화61례급성심기경사（AMI）환자]적혈장ATⅡ、NPY、IGF-1화hs-CRP수평，병여60명정상대조자진행대비분석。결과157례CHD환자혈장ATⅡ수평여60명정상대조자상비，차이유통계학의의（tSA ATⅡ=2．257，P＜0．05；tUSA ATⅡ=3．018，P＜0．01；tAMI ATⅡ=4．143，P＜0．001）；혈장NPY수평교정상대조자증고（tSA NPY=1．413，P＞0．05；tUSA NPY=2．148，P＜0．05；tAMI NPY=3．068，P＜0．01），단SA환자여정상대조자지간적차이무통계학의의；혈장IGF-1수평여정상대조자상비，차이유통계학의의（tSA IGF-1=2．121，P＜0．05；tUSA IGF-1=2．937，P＜0．01；tAMIIGF-1=4．217，P＜0．001）；혈장hs-CRP수평여정상대조자상비，차이유통계학의의（tSAhs-CRP=2．095，P＜0．05；tUSA hs-CRP=2．867，P＜0．01；tAMI hs-CRP=4．349，P＜0．001）。혈장ATⅡ、NPY、IGF-1화hs-CRP수평수착SA、USA화AMI환자적엄중정도이증고。결론혈장ATⅡ、NPY、IGF-1화hs-CRP수평시판단관심병환자엄중정도적유개치지표，역가이용우치료후적수방。
Objective To explore the application value of angiotensinⅡ (ATⅡ), neuropeptide Y(NPY), insulin-like growth factor 1(IGF-1) and high sensitive C-reaction protein(hs-CRP) levels in e-valuation of the severity of coronary heart disease (CHD). Methods The plasma ATⅡ, NPY, IGF-1 and hs-CRP levels in 157 patients with CHD [ including 51 cases with stable angina ( SA ) , 45 cases with unstable angina (USA) and 61 cases with acute myocardial infraction (AMI)] were measured by radioim-munoassay, enzyme immunoassay and high sensitive enzyme immunoassay and were compared with 60 health controls. Results The plasma ATⅡlevel in 157 patients with CHD was significantly higher than those in 60 controls(tSA ATⅡ=2.257, P<0.05; tUSAATⅡ=3.018, P<0.01; tAMIATⅡ=4.143, P<0.001). The plasma NPY level in 157 patients with CHD was higher than those in 60 controls (tSANPY=1.413, P>0.05;tUSANPY=2.148, P<0.05; tAMINPY=3.068, P<0.01), but there were no significant difference between SA pa-tients and the 60 conrols. The plasma IGF-1 level in 157 patients with CHD was significantly higher than those in 60 controls (tSA IGF-1=2.121, P<0.05; tUSA IGF-1=2.937, P<0.01; tAMI IGF-1=4.217, P<0.001). The plasma hs-CRP level in 157 patients with CHD was significantly higher than those in 60 controls (tSA hs-CRP=2.095, P<0.05; tUSA hs-CRP=2.867, P<0.01; tAMI hs-CRP=4.349, P<0.001). The four plasma biomarkers were increased with severity of CHD. Conclusion The plasma ATⅡ, NPY, IGF-1 and hs-CRP levels were valuable indexes for judging the severity of patients with CHD, and could be used for follow-up.
