中国医学前沿杂志（电子版）
中國醫學前沿雜誌（電子版）
중국의학전연잡지（전자판）
CHINESE JOURNAL OF THE FRONTIERS OF MEDICAL SCIENCE(ELECTRONIC VERSION)
2014年
5期
103-105
,共3页
消化性溃疡%幽门螺杆菌%胃泌素基因%血清胃泌素
消化性潰瘍%幽門螺桿菌%胃泌素基因%血清胃泌素
소화성궤양%유문라간균%위비소기인%혈청위비소
Peptic ulcer%Helicobacter pylori%The stomach secrete hormone gene%Serum gastric secrete element
目的：研究消化性溃疡患者幽门螺杆菌根除治疗对其血清胃泌素及胃泌素基因表达的影响。方法选择本院收治的幽门螺杆菌阳性消化性溃疡患者88例，给予质子泵抑制剂、甲硝唑和阿莫西林治疗，检测患者治疗前后胃泌素基因表达和血清胃泌素水平。结果胃溃疡组和十二指肠溃疡组治疗效果相似。胃溃疡组根除幽门螺杆菌患者的胃泌素基因表达水平降低，但是胃泌素浓度与未根除的患者比较差异无显著性（P＞0.05）。十二指肠溃疡组根除幽门螺杆菌患者胃泌素基因表达水平与胃泌素浓度降低幅度均优于未根除患者，差异具有显著性（P＜0.05）。结论幽门螺杆菌感染会导致胃泌素基因表达水平升高、胃泌素分泌增多，且与十二指肠溃疡发生密切相关，对于胃溃疡患者，幽门螺杆菌不仅与胃泌素基因表达水平相关，还同胃酸负反馈等其他因素相关。
目的：研究消化性潰瘍患者幽門螺桿菌根除治療對其血清胃泌素及胃泌素基因錶達的影響。方法選擇本院收治的幽門螺桿菌暘性消化性潰瘍患者88例，給予質子泵抑製劑、甲硝唑和阿莫西林治療，檢測患者治療前後胃泌素基因錶達和血清胃泌素水平。結果胃潰瘍組和十二指腸潰瘍組治療效果相似。胃潰瘍組根除幽門螺桿菌患者的胃泌素基因錶達水平降低，但是胃泌素濃度與未根除的患者比較差異無顯著性（P＞0.05）。十二指腸潰瘍組根除幽門螺桿菌患者胃泌素基因錶達水平與胃泌素濃度降低幅度均優于未根除患者，差異具有顯著性（P＜0.05）。結論幽門螺桿菌感染會導緻胃泌素基因錶達水平升高、胃泌素分泌增多，且與十二指腸潰瘍髮生密切相關，對于胃潰瘍患者，幽門螺桿菌不僅與胃泌素基因錶達水平相關，還同胃痠負反饋等其他因素相關。
목적：연구소화성궤양환자유문라간균근제치료대기혈청위비소급위비소기인표체적영향。방법선택본원수치적유문라간균양성소화성궤양환자88례，급여질자빙억제제、갑초서화아막서림치료，검측환자치료전후위비소기인표체화혈청위비소수평。결과위궤양조화십이지장궤양조치료효과상사。위궤양조근제유문라간균환자적위비소기인표체수평강저，단시위비소농도여미근제적환자비교차이무현저성（P＞0.05）。십이지장궤양조근제유문라간균환자위비소기인표체수평여위비소농도강저폭도균우우미근제환자，차이구유현저성（P＜0.05）。결론유문라간균감염회도치위비소기인표체수평승고、위비소분비증다，차여십이지장궤양발생밀절상관，대우위궤양환자，유문라간균불부여위비소기인표체수평상관，환동위산부반궤등기타인소상관。
ObjectiveTostudy the effection of helicobacter pylori eradication in peptic ulcer patients of stomach gastrin-releasing gene expression and serum gastrin-releasing.Methods88 cases of helicobacter pylori positive peptic ulcer patients, were given pharmacological proton pump inhibitors, treatment of metronidazole and amoxicillin, observed gastric secrete element gene expression and serum levels before and after treatment. ResultsGastric and duodenal ulcer group treatment effect comparison differences have no statistical signiifcance (P>0.05). Gastric ulcer group, the eradication of helicobacter pylori in patients with gastric secrete element to reduce the level of gene expression, but the stomach secrete hormone concentration compared with patients who were not eradicate the difference is not statistically signiifcant (P>0.05). Duodenal ulcer group of helicobacter pylori eradication in patients with gastric secrete element with gastric secrete element concentration reduction of the level of gene expression are better than not eradicate patients, data comparison between groups, the difference was statistically signiifcant (P<0.05).ConclusionHelicobacter pylori infection causes gastric secrete element and the stomach secrete hormone secretion increased, the level of gene expression and is closely related to duodenal ulcer occurred, for patients with gastric ulcer and gastric secrete element not only related gene expression level also may be related to other factors such as hydrochloric acid in gastric juice negative feedback.
