CAJ | 학술논문

目的：研究胃食管反流病患者伴或不伴食管损伤与食管动力及酸反流之间的相关性。方法选取2012年1月至2013年8月在本院就诊的胃食管反流患者75例，分别进行胃镜检查、高分辨率食管测压检查及进食标准试验餐后的动态食管pH检测。比较伴食管损伤组和不伴食管损伤组患者之间的食管动力及餐后酸反流时间之间的差异，并比较酸反流组患者与非酸反流组患者之间食管动力的差异是否有显著性。结果伴食管损伤组与不伴食管损伤组患者下食管括约肌压力基础值、下食管括约肌压力残余平均值、食管蠕动传播速度、食管pH＜4的时间及食管pH＜4的Demeester评分差异无显著性（P均＜0.05）；不伴食管损伤组患者的食管收缩幅度大于伴食管损伤组，差异有显著性（P＜0.05）；酸反流组与非酸反流组患者下食管括约肌压力基础值、下食管括约肌压力残余平均值及食管蠕动传播速度的差异无显著性（P均＞0.05）；酸反流组患者的食管收缩幅度弱于非酸反流组，差异有显著性（P＜0.05）。结论胃食管反流患者食管蠕动性收缩功能可能与食管损伤及酸反流有关，但是下食管括约肌压力与食管损伤及酸反流无关。
목적：연구위식관반류병환자반혹불반식관손상여식관동력급산반류지간적상관성。방법선취2012년1월지2013년8월재본원취진적위식관반류환자75례，분별진행위경검사、고분변솔식관측압검사급진식표준시험찬후적동태식관pH검측。비교반식관손상조화불반식관손상조환자지간적식관동력급찬후산반류시간지간적차이，병비교산반류조환자여비산반류조환자지간식관동력적차이시부유현저성。결과반식관손상조여불반식관손상조환자하식관괄약기압력기출치、하식관괄약기압력잔여평균치、식관연동전파속도、식관pH＜4적시간급식관pH＜4적Demeester평분차이무현저성（P균＜0.05）；불반식관손상조환자적식관수축폭도대우반식관손상조，차이유현저성（P＜0.05）；산반류조여비산반류조환자하식관괄약기압력기출치、하식관괄약기압력잔여평균치급식관연동전파속도적차이무현저성（P균＞0.05）；산반류조환자적식관수축폭도약우비산반류조，차이유현저성（P＜0.05）。결론위식관반류환자식관연동성수축공능가능여식관손상급산반류유관，단시하식관괄약기압력여식관손상급산반류무관。
ObjectiveTo study the relation of esophageal motility and acid relfux between gastroesophageal reflux disease (GERD) patients with and without esophageal injury.Methods75 cases of patients with gastroesophageal reflux from January 2012 to August 2013 were conducted esophageal-gastric-duodenal endoscopy examination and followed with high-resolution esophageal manometry, and detected the changes of esophageal pH postprandial,. The differences of esophageal motility and acid relfux time between esophageal injury group and without esophageal injury group were compared, and the changes of esophageal motility indexes between non acid relfux and acid relfux group were compared whether there is statistical signiifcance. ResultsThere was no significant difference in baseline value of lower esophageal sphincter pressure, remained lower esophageal sphincter pressure, speed of the esophageal peristalsis, the time of esophageal pH<4 and DeMeester score between groups with and without esophageal injury (allP>0.05), esophageal contraction amplitude of group with without esophageal injury was higher than that of esophageal injury group, which had signiifcant difference (P<0.05). There was no signiifcant difference in baseline value of ower esophageal sphincter pressure, remained LES pressure, speed of the esophageal peristalsis between acid relfux group and non acid relfux group (allP>0.05), the esophageal contraction amplitude of acid relfux group was lower than that of non acid relfux group, which had signiifcant difference (P<0.05). The difference was not statistically signiifcant.ConclusionsThere was no signiifcant correlation between the lower esophageal sphincter pressure and esophageal acid relfux with esophageal injury in GERD patients. But esophageal peristalie contraction may be associated with esophageal injury and acid relfux.