世界科学技术-中医药现代化
世界科學技術-中醫藥現代化
세계과학기술-중의약현대화
WORLD SCIENCE AND TECHNOLOGY-MODERNIZATION OF TRADITIONAL CHINESE MEDICINE
2014年
5期
1128-1132
,共5页
胸腔镜%证型%细支气管肺泡细胞癌%转移%内外合诊
胸腔鏡%證型%細支氣管肺泡細胞癌%轉移%內外閤診
흉강경%증형%세지기관폐포세포암%전이%내외합진
Thoracoscope%syndrome%bronchioloalveolar carcinoma%metastasis internal and external inspection
目的：揭示细支气管肺泡细胞癌（BAC）证型与肿瘤转移相关性，为该病辨证论治及预后评估提供新的科学依据，进而证实内外合诊科学性及可行性。方法：60例BAC患者按照虚实证型平均分成两组，同期收集体检肺部良性结节者30例，设为对照组，各组患者术前一天行生活质量（FACT-L）评分，术中运用胸腔镜技术取出靶组织活检，开展肿瘤转移相关指标的对照研究。结果：BAC两证型组患者FACT-L评分与对照组比较，前者生理状况、社会/家庭状况、情感状况、功能状况、附加状况评分及总评分显著高于后者（P<0.01），而虚证组患者较实证组评分偏高，且差异有统计学意义（P<0.01）；BAC两证型组患者肿瘤组织与良性结节组织比较，前者VEGF、MMP-2、MMP-9皆高于后者（P<0.01），两证型组间比较，上述指标虚证患者高于实证患者（P<0.01）。结论：细支气管肺泡细胞癌证型与肿瘤转移存在相关性。
目的：揭示細支氣管肺泡細胞癌（BAC）證型與腫瘤轉移相關性，為該病辨證論治及預後評估提供新的科學依據，進而證實內外閤診科學性及可行性。方法：60例BAC患者按照虛實證型平均分成兩組，同期收集體檢肺部良性結節者30例，設為對照組，各組患者術前一天行生活質量（FACT-L）評分，術中運用胸腔鏡技術取齣靶組織活檢，開展腫瘤轉移相關指標的對照研究。結果：BAC兩證型組患者FACT-L評分與對照組比較，前者生理狀況、社會/傢庭狀況、情感狀況、功能狀況、附加狀況評分及總評分顯著高于後者（P<0.01），而虛證組患者較實證組評分偏高，且差異有統計學意義（P<0.01）；BAC兩證型組患者腫瘤組織與良性結節組織比較，前者VEGF、MMP-2、MMP-9皆高于後者（P<0.01），兩證型組間比較，上述指標虛證患者高于實證患者（P<0.01）。結論：細支氣管肺泡細胞癌證型與腫瘤轉移存在相關性。
목적：게시세지기관폐포세포암（BAC）증형여종류전이상관성，위해병변증론치급예후평고제공신적과학의거，진이증실내외합진과학성급가행성。방법：60례BAC환자안조허실증형평균분성량조，동기수집체검폐부량성결절자30례，설위대조조，각조환자술전일천행생활질량（FACT-L）평분，술중운용흉강경기술취출파조직활검，개전종류전이상관지표적대조연구。결과：BAC량증형조환자FACT-L평분여대조조비교，전자생리상황、사회/가정상황、정감상황、공능상황、부가상황평분급총평분현저고우후자（P<0.01），이허증조환자교실증조평분편고，차차이유통계학의의（P<0.01）；BAC량증형조환자종류조직여량성결절조직비교，전자VEGF、MMP-2、MMP-9개고우후자（P<0.01），량증형조간비교，상술지표허증환자고우실증환자（P<0.01）。결론：세지기관폐포세포암증형여종류전이존재상관성。
This study was aimed to reveal the relationship of bronchioloalveolar carcinoma (BAC) syndromes and metastasis, in order to provide new scientific basis for syndrome differentiation, treatment and prognostic assessment, which proved the scientificity and feasibility of internal and external inspection. A total of 60 BAC cases were divid-ed into two groups according to the syndrome of deficiency and excess. Another 30 cases of benign pulmonary nod-ules were simultaneous collected in the physical examination as control group. The quality of life (FACT-L) was scored one day before operation for patients in each group. The thoracoscopic technique was used in the biopsy of targeted tissues, in order to reveal indicators related with metastasis. The results showed that the comparison of FACT-L score of patients from two syndromes of BAC and that of the control group indicated that the score of physi-ological state, social/family condition, emotional condition, functional situation, additional situation and total score of the previous one were obviously higher than the latter one (P < 0.01). And the score of patients in the deficiency syndrome group was higher than that of the excess group with statistical significance (P< 0.01). The comparison be-tween the tumor tissues of patients from two syndromes of BAC and the benign pulmonary nodules showed that the VEGF, MMP-2, MMP-9 of the previous one were higher than the latter one (P< 0.01). The comparison between two syndromes showed that all indexes of the deficiency syndrome were higher than the excess syndrome (P < 0.01). It was concluded that syndromes of BAC was related with metastasis.
