CAJ | 학술논문

目的：评价桑蒺合剂干预高血压病（肝火亢盛夹痰证）患者外周血单核细胞表面 Toll 样受体4（TLR4）表达的作用。方法：60例高血压肝火亢盛夹痰证患者，随机分为治疗组和对照组各30例，均给予非洛地平或联合贝那普利治疗，治疗组加用桑蒺合剂，观察周期28天，检测治疗前后血压、中医证候积分、外周血单核细胞表面TLR4表达。结果：治疗后两组患者血压水平、中医证候积分、TLR4表达均较治疗前降低，其中治疗组中医证候积分、TLR4表达较对照组改变更明显（P<0.05）。结论：桑蒺合剂可改善肝火亢盛夹痰证患者的临床症状，减少外周血单核细胞表面TLR4表达，在一定程度上可以抑制免疫反应。
목적：평개상질합제간예고혈압병（간화항성협담증）환자외주혈단핵세포표면 Toll 양수체4（TLR4）표체적작용。방법：60례고혈압간화항성협담증환자，수궤분위치료조화대조조각30례，균급여비락지평혹연합패나보리치료，치료조가용상질합제，관찰주기28천，검측치료전후혈압、중의증후적분、외주혈단핵세포표면TLR4표체。결과：치료후량조환자혈압수평、중의증후적분、TLR4표체균교치료전강저，기중치료조중의증후적분、TLR4표체교대조조개변경명현（P<0.05）。결론：상질합제가개선간화항성협담증환자적림상증상，감소외주혈단핵세포표면TLR4표체，재일정정도상가이억제면역반응。
This study was aimed to observe the effect of Sang-Ji (SJ) mixture in the treatment of Toll-like receptor 4 (TLR-4) expression on peripheral blood monocytes (PBMCs) in hypertensive patients. A total of 60 cases of hyper-tensive cases with overabundant liver-fire and phlegm syndrome were randomly divided into the treatment group and the control group with 30 cases in each group. Both groups received Felodipine and/or Benazapril treat-ment. The treatment group was added with SJ mixture. The observation duration was 28 days. The detection was made on indicators such as blood pressure , traditional Chinese medicine ( TCM ) syndrome scores and TLR-4 ex-pression on PBMCs before and after treatment. The results showed that after treatment, the blood pressure, TCM syndrome scores and TLR-4 expression on PBMCs of both groups decreased compared with that of the pretreat-ment . Changes on TCM syndrome scores and TLR-4 expression of the treatment group were more significant than that of the control group ( P < 0 . 05 ) . It was concluded that SJ mixture improved clinical symptoms in pa-tients with overabundant liver-fire and phlegm syndrome , decreased TLR-4 expression on PBMCs , in order to inhibit the immune response to a certain extent .