巨噬细胞极化及其在动脉粥样硬化发生发展中的作用
거서세포겁화급기재동맥죽양경화발생발전중적작용
Macrophage Polarization and Its Role in Development of Atherosclerosis
  • 万方数据
    世界科学技术-中医药现代化 세계과학기술-중의약현대화
    WORLD SCIENCE AND TECHNOLOGY-MODERNIZATION OF TRADITIONAL CHINESE MEDICINE
    2014年 5期 1065-1070 ,共6页

    周冰冰%李玉洁%李琦%杨庆%翁小刚%陈颖%王娅杰%郭琰%刘栩岑%巩仔鹏%阚晓溪%张瑞杰%朱晓新

    주빙빙%리옥길%리기%양경%옹소강%진영%왕아걸%곽염%류허잠%공자붕%감효계%장서걸%주효신

    动脉粥样硬化%单核-巨噬细胞%巨噬细胞极化%M1型巨噬细胞%M2型巨噬细胞 動脈粥樣硬化%單覈-巨噬細胞%巨噬細胞極化%M1型巨噬細胞%M2型巨噬細胞
    동맥죽양경화%단핵-거서세포%거서세포겁화%M1형거서세포%M2형거서세포
    Atherosclerosis%monocyte-macrophage%macrophage polarization%M1 macrophages%M2 macrophages
    动脉粥样硬化（As）是心脑血管疾病的重要病理基础，其发病机制一直是血管生物学研究领域的热点问题。炎症是As发生、发展过程中的主要因素，而与炎症发生关系最紧切的细胞是单核-巨噬细胞。近几年随着对 As炎症机制研究的不断深入，巨噬细胞极化分型引起了研究者们的关注。在不同环境影响下，巨噬细胞可分为 M1型和 M2型，一般认为 M1型（经典活化型）为促炎亚型，分泌促炎因子，因此促进 As 的进展；而 M2型（替代活化型）为抑炎亚型，可以抑制促炎因子的产生，其有可能延缓As发展进程。该文就巨噬细胞的极化分型，以及在 As的形成和发展过程中的影响等予以综述，并展望中药在防治As中的机制。
    동맥죽양경화（As）시심뇌혈관질병적중요병리기출，기발병궤제일직시혈관생물학연구영역적열점문제。염증시As발생、발전과정중적주요인소，이여염증발생관계최긴절적세포시단핵-거서세포。근궤년수착대 As염증궤제연구적불단심입，거서세포겁화분형인기료연구자문적관주。재불동배경영향하，거서세포가분위 M1형화 M2형，일반인위 M1형（경전활화형）위촉염아형，분비촉염인자，인차촉진 As 적진전；이 M2형（체대활화형）위억염아형，가이억제촉염인자적산생，기유가능연완As발전진정。해문취거서세포적겁화분형，이급재 As적형성화발전과정중적영향등여이종술，병전망중약재방치As중적궤제。
    Atherosclerosis (As) is an important pathological basis of cardiovascular and cerebrovascular diseases. The pathogenesis studies of As have been a hot topic in the field of vascular biology research. The inflammation is known as a major participant in the development process of As. And monocyte-macrophage plays a central role in inflam-mation. In recent years, with the deepening research on inflammatory mechanisms, the As macrophage polarization is attracting researchers' attention. Under different environmental inductions, macrophages develop into M1 and M2 phenotypes. M1 macrophages (classical type), which can stimulate the secretion of pro-inflammatory cytokines, is generally considered as pro-inflammatory subtypes and can facilitate the progress of As. Whereas, M2 macrophages (alternative type), which can inhibit pro-inflammatory factor production, function as anti-inflammatory subtypes and likely to inhibit the progression of As. The mechanisms of As, macrophage polarization in As, and opportunities for herbal medicines will be summarized in this review.
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