CAJ | 학술논문

目的：总结自体瓣膜感染性心内膜炎（ NVE）患者的治疗经验，探讨手术时机的选择对患者感染控制、心功能恢复以及远期死亡率的影响。方法对2006年1月至2013年5月入选的80例NVE患者均应用抗生素治疗，并根据手术时机分为早期手术组38例，晚期手术组42例。同时将患者手术前、后感染相关指标，心功能指标以及术后1年、3年及5年的死亡率进行对比分析。结果早期手术组患者感染控制、心功能的恢复较晚期手术组好（P＜0．05），差异有统计学意义，而且术后3年及5年的死亡率两组比较，差异具有统计学意义。结论对于NVE患者除常规应用抗生素治疗外，早期手术组患者的治疗效果及远期生存率均明显优于晚期手术组。
목적：총결자체판막감염성심내막염（ NVE）환자적치료경험，탐토수술시궤적선택대환자감염공제、심공능회복이급원기사망솔적영향。방법대2006년1월지2013년5월입선적80례NVE환자균응용항생소치료，병근거수술시궤분위조기수술조38례，만기수술조42례。동시장환자수술전、후감염상관지표，심공능지표이급술후1년、3년급5년적사망솔진행대비분석。결과조기수술조환자감염공제、심공능적회복교만기수술조호（P＜0．05），차이유통계학의의，이차술후3년급5년적사망솔량조비교，차이구유통계학의의。결론대우NVE환자제상규응용항생소치료외，조기수술조환자적치료효과급원기생존솔균명현우우만기수술조。
Objective To summarize experience in treating patients with native value endocarditis ( NVE) , and discuss the effect of timing of surgery on the infection control , cardiac function recovery and long-term mortality among patients . Methods Eighty NVE cases with antibiotic treatment were recruited between January 2006 and May 2013 .According to the timing of surgery, the subjects were divided into the early surgery group (38 cases) and the late surgery group (42 ca-ses) .The infection-related markers and cardiac function indexes before and after surgery , and 1-year, 3-year and 5-year mortality after surgery were analyzed .Results The infection control and recovery of cardiac function in the early surgery group were better than in the late surgery group (P<0.05).The difference in 3-year and 5-year mortalities between the two groups was significant .Conclusions For NVE patients with routine antibiotics treatment , the surgical effect and long-term survival rate are much better in the early surgery group than in the late surgery group .