中西医结合心脑血管病杂志
中西醫結閤心腦血管病雜誌
중서의결합심뇌혈관병잡지
CHINESE JOURNAL OF INTEGRATIVE MEDICINE ON CARDIO-/CEREBROVASCULAR DISEASE
2014年
6期
662-664
,共3页
慎柔养真汤%阿托伐他汀钙%脾阴虚%脂蛋白异常血症
慎柔養真湯%阿託伐他汀鈣%脾陰虛%脂蛋白異常血癥
신유양진탕%아탁벌타정개%비음허%지단백이상혈증
modified Shenrou Yangzhen decoction%atorvastatin calcium%spleen yin deficiency syndrome%dyslipoproteinemia
目的：探讨加味慎柔养真汤联合阿托伐他汀钙治疗脾阴虚型脂蛋白异常血症的临床疗效及其对脂代谢的影响。方法将符合纳入标准的脾阴虚型脂蛋白异常血症60例患者,随机分为治疗组和对照组,每组30例。对照组予以阿托伐他汀钙片治疗,每次10 mg,每日1次；治疗组在对照组治疗基础上加服加味慎柔养真汤,每日1剂,疗程4周。治疗后观察两组的临床疗效,并比较两组治疗前后血清脂蛋白的变化。结果治疗组实验室检查疗效总有效率为93.33%,对照组为73.33%,两组比较差异有统计学意义(P<0.05)。治疗组中医临床证候疗效总有效率为90.00%,优于对照组的66.67%,差异有统计学意义(P<0.05)。两组治疗后血清三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL C)含量均显著降低(P<0.05),高密度脂蛋白胆固醇(HDL C)含量显著升高(P<0.05),治疗组降低TG及升高 HDL C的效果均优于对照组(P<0.05或P<0.01)。结论加味慎柔养真汤联合阿托伐他汀钙对脾阴虚型脂蛋白异常血症患者具有良好的调脂作用,且能明显改善患者脾阴虚的症状,较单纯西药治疗有效。
目的：探討加味慎柔養真湯聯閤阿託伐他汀鈣治療脾陰虛型脂蛋白異常血癥的臨床療效及其對脂代謝的影響。方法將符閤納入標準的脾陰虛型脂蛋白異常血癥60例患者,隨機分為治療組和對照組,每組30例。對照組予以阿託伐他汀鈣片治療,每次10 mg,每日1次；治療組在對照組治療基礎上加服加味慎柔養真湯,每日1劑,療程4週。治療後觀察兩組的臨床療效,併比較兩組治療前後血清脂蛋白的變化。結果治療組實驗室檢查療效總有效率為93.33%,對照組為73.33%,兩組比較差異有統計學意義(P<0.05)。治療組中醫臨床證候療效總有效率為90.00%,優于對照組的66.67%,差異有統計學意義(P<0.05)。兩組治療後血清三酰甘油(TG)、總膽固醇(TC)、低密度脂蛋白膽固醇(LDL C)含量均顯著降低(P<0.05),高密度脂蛋白膽固醇(HDL C)含量顯著升高(P<0.05),治療組降低TG及升高 HDL C的效果均優于對照組(P<0.05或P<0.01)。結論加味慎柔養真湯聯閤阿託伐他汀鈣對脾陰虛型脂蛋白異常血癥患者具有良好的調脂作用,且能明顯改善患者脾陰虛的癥狀,較單純西藥治療有效。
목적：탐토가미신유양진탕연합아탁벌타정개치료비음허형지단백이상혈증적림상료효급기대지대사적영향。방법장부합납입표준적비음허형지단백이상혈증60례환자,수궤분위치료조화대조조,매조30례。대조조여이아탁벌타정개편치료,매차10 mg,매일1차；치료조재대조조치료기출상가복가미신유양진탕,매일1제,료정4주。치료후관찰량조적림상료효,병비교량조치료전후혈청지단백적변화。결과치료조실험실검사료효총유효솔위93.33%,대조조위73.33%,량조비교차이유통계학의의(P<0.05)。치료조중의림상증후료효총유효솔위90.00%,우우대조조적66.67%,차이유통계학의의(P<0.05)。량조치료후혈청삼선감유(TG)、총담고순(TC)、저밀도지단백담고순(LDL C)함량균현저강저(P<0.05),고밀도지단백담고순(HDL C)함량현저승고(P<0.05),치료조강저TG급승고 HDL C적효과균우우대조조(P<0.05혹P<0.01)。결론가미신유양진탕연합아탁벌타정개대비음허형지단백이상혈증환자구유량호적조지작용,차능명현개선환자비음허적증상,교단순서약치료유효。
Objective To investigate the effect of modified Shenrou Yangzhen decoction (MSYD)combined with atorvastatin cal-cium in the treatment of dyslipoproteinemia with Spleen yin deficiency syndrome.Methods Sixty dyslipoproteinemia patients with spleen yin deficiency syndrome were randomly divided into two groups:Control group (n=30)treated by atorvastatin calcium,and treatment group (n=30)treated by MSYD for 4 weeks.The total effective rate was observed after treatment,and the serum lipopro-tein were compared before and after treatment.Results The total effective rate was 93.33% in treatment group and 73.33% in con-trol group.There was statistical difference between two groups (P<0.05).The effective rate of TCM clinical syndromes in treatment group was 90.00%,which was higher than that in control group (66.67%,P<0.05).After treatment,the serum TG,TC and LDL C in both groups decreased significantly (P<0.05),while the content of HDL C increased obviously (P<0.05).The improvements of TG and HDL C were superior in treatment group than those in control group (P<0.05 or P<0.01).Conclusion MSYD combined with atorvastatin calcium had a good effect on the improvement of lipoprotein in treating dyslipoproteinemia with spleen yin deficien-cy syndrome,and improvement of spleen yin deficiency syndrome.
