CAJ | 학술논문

calpains是一类由 Ca2+激活的内源性半胱氨酸蛋白酶。尽管先前研究认为calpains是一种胞质酶，最近研究发现μ-calpain、m-calpain、calpain10以及内源性抑制剂 cal-pastatin也同时存在于线粒体中，在caspase依赖型和非依赖型细胞凋亡通路中均发挥着重要的作用。 calpain 除了与caspase相互作用外，还可剪切凋亡相关蛋白如 Bcl-2、Bax、Bid等，促进Cyt-C、AIF的释放，从而参与调控细胞凋亡的病理过程。 calpains作为潜在的治疗靶点，研究线粒体calpains与细胞凋亡通路的关系具有重大意义。
calpains시일류유 Ca2+격활적내원성반광안산단백매。진관선전연구인위calpains시일충포질매，최근연구발현μ-calpain、m-calpain、calpain10이급내원성억제제 cal-pastatin야동시존재우선립체중，재caspase의뢰형화비의뢰형세포조망통로중균발휘착중요적작용。 calpain 제료여caspase상호작용외，환가전절조망상관단백여 Bcl-2、Bax、Bid등，촉진Cyt-C、AIF적석방，종이삼여조공세포조망적병리과정。 calpains작위잠재적치료파점，연구선립체calpains여세포조망통로적관계구유중대의의。
Calpains are the family of Ca2+-activated cysteine pro-teases. Although calpains are considered to be cytoplasmic en-zymes, recent research has demonstrated that μ-calpain, m-cal-pain, calpain 10 and their endogenous inhibitor calpastatin are present in the mitochondria and play important roles both in caspase -dependent and-independent pathways in cell death phe-nomena. Calpains exert direct and indirect effects on the caspases <br> and regulators of apoptosis pathway such as Bcl-2, Bax, Bid, promoting the release of Cyt-C, AIF, then result in cellular ap-optosis. To allow pharmacological targeting of these enzymes, thorough knowledge of their patterns of activation and further in-teractions with already known apoptotic pathways is necessary.