CAJ | 학술논문

催产素(oxytocin, OT)是一个含有9个氨基酸残基的环状神经肽,除了传统的缩宫和泌乳作用外,近年来, OT在中枢神经系统及其它外周器官的新功能也受到广泛关注,如改善精神分裂症、自闭症和焦虑症等精神心理症状。 OT通过与其受体(oxytocin receptor, OTR)结合而发挥生理作用,目前研究人员以OT信号系统作为药物靶标,通过开发新型OTR配体(即激动剂和拮抗剂)来预防和改善相应症状。该文从OTR药理学角度对其激动剂和拮抗剂及其生物学功能的最新研究进展进行了综述。
최산소(oxytocin, OT)시일개함유9개안기산잔기적배상신경태,제료전통적축궁화비유작용외,근년래, OT재중추신경계통급기타외주기관적신공능야수도엄범관주,여개선정신분렬증、자폐증화초필증등정신심리증상。 OT통과여기수체(oxytocin receptor, OTR)결합이발휘생리작용,목전연구인원이OT신호계통작위약물파표,통과개발신형OTR배체(즉격동제화길항제)래예방화개선상응증상。해문종OTR약이학각도대기격동제화길항제급기생물학공능적최신연구진전진행료종술。
Oxytocin ( OT ) is a cyclic neuropeptide containing nine amino acids residues, in addition to the traditional roles of uterine contraction and lactation, it also plays important roles in the central nervous system and other peripheral organs, such as improving schizophrenia, autism - related psychiatric and psy-chological symptoms. Oxytocin exhibits its physiological func-tions by binding to its receptor (oxytocin receptor,OTR). Cur- <br> rently researchers are manipulating OT system by developing new OTR ligand ( agonists and antagonists ) , hoping to prevent and treat OTR related diseases. This paper reviews the latest devel-opment of OTR agonists, antagonists and its physiological roles in central nerve system and peripheral organs.