中华检验医学杂志
中華檢驗醫學雜誌
중화검험의학잡지
CHINESE JOURNAL OF LABORATORY MEDICINE
2014年
6期
444-446
,共3页
肺肿瘤%肿瘤转移%红细胞指数
肺腫瘤%腫瘤轉移%紅細胞指數
폐종류%종류전이%홍세포지수
Lung neoplasms%Neoplasm metastasis%Erythrocyte indices
目的:探讨红细胞分布宽度( RDW)在提示肺癌患者转移中的临床应用价值。方法回顾性分析上海市胸科医院2012年1月至2013年7月525例初诊肺癌患者的病历资料和全血RDW数据。对全部525例患者根据分期、有无转移等分组,并进一步对其中405例有转移者根据转移程度及其中246例有远端转移者根据远端转移器官数分别分组。多组间计量资料的比较用Kruskal-Wallis H检验,RDW与临床参数间的相关性用Spearman相关性分析。结果肺癌转移患者外周血RDW水平为14.5(13.0~15.4)%,显著高于未转移者[12.7(12.3~13.0)%],差异有统计学意义(U=8597.500,P<0.05)。对于不同分期的肺癌患者,Ⅲ期、Ⅳ期组的 RDW[14.6(12.9~15.4)%]显著高于Ⅰ、Ⅱ期组[12.6(12.2~13.1)%],差异有统计学意义(U=8549.000,P<0.05)。 RDW与分期、是否转移有一定相关性(r=0.508、0.470,P均<0.05)。 ROC曲线分析表明,RDW鉴别诊断肺癌是否发生转移、远端转移的曲线下面积(AUC)分别为0.823(95% CI:0.787~0.859)和0.710(95%CI:0.655~0.765)。以Youden指数最大时的切点作为诊断肺癌转移的cut-off值(14.25%),此时敏感度为56.8%,特异度为98.3%,具有一定准确性。结论 RDW值的变化对判断肺癌患者转移情况有一定的应用价值。(中华检验医学杂志,2014,37:444-446)
目的:探討紅細胞分佈寬度( RDW)在提示肺癌患者轉移中的臨床應用價值。方法迴顧性分析上海市胸科醫院2012年1月至2013年7月525例初診肺癌患者的病歷資料和全血RDW數據。對全部525例患者根據分期、有無轉移等分組,併進一步對其中405例有轉移者根據轉移程度及其中246例有遠耑轉移者根據遠耑轉移器官數分彆分組。多組間計量資料的比較用Kruskal-Wallis H檢驗,RDW與臨床參數間的相關性用Spearman相關性分析。結果肺癌轉移患者外週血RDW水平為14.5(13.0~15.4)%,顯著高于未轉移者[12.7(12.3~13.0)%],差異有統計學意義(U=8597.500,P<0.05)。對于不同分期的肺癌患者,Ⅲ期、Ⅳ期組的 RDW[14.6(12.9~15.4)%]顯著高于Ⅰ、Ⅱ期組[12.6(12.2~13.1)%],差異有統計學意義(U=8549.000,P<0.05)。 RDW與分期、是否轉移有一定相關性(r=0.508、0.470,P均<0.05)。 ROC麯線分析錶明,RDW鑒彆診斷肺癌是否髮生轉移、遠耑轉移的麯線下麵積(AUC)分彆為0.823(95% CI:0.787~0.859)和0.710(95%CI:0.655~0.765)。以Youden指數最大時的切點作為診斷肺癌轉移的cut-off值(14.25%),此時敏感度為56.8%,特異度為98.3%,具有一定準確性。結論 RDW值的變化對判斷肺癌患者轉移情況有一定的應用價值。(中華檢驗醫學雜誌,2014,37:444-446)
목적:탐토홍세포분포관도( RDW)재제시폐암환자전이중적림상응용개치。방법회고성분석상해시흉과의원2012년1월지2013년7월525례초진폐암환자적병력자료화전혈RDW수거。대전부525례환자근거분기、유무전이등분조,병진일보대기중405례유전이자근거전이정도급기중246례유원단전이자근거원단전이기관수분별분조。다조간계량자료적비교용Kruskal-Wallis H검험,RDW여림상삼수간적상관성용Spearman상관성분석。결과폐암전이환자외주혈RDW수평위14.5(13.0~15.4)%,현저고우미전이자[12.7(12.3~13.0)%],차이유통계학의의(U=8597.500,P<0.05)。대우불동분기적폐암환자,Ⅲ기、Ⅳ기조적 RDW[14.6(12.9~15.4)%]현저고우Ⅰ、Ⅱ기조[12.6(12.2~13.1)%],차이유통계학의의(U=8549.000,P<0.05)。 RDW여분기、시부전이유일정상관성(r=0.508、0.470,P균<0.05)。 ROC곡선분석표명,RDW감별진단폐암시부발생전이、원단전이적곡선하면적(AUC)분별위0.823(95% CI:0.787~0.859)화0.710(95%CI:0.655~0.765)。이Youden지수최대시적절점작위진단폐암전이적cut-off치(14.25%),차시민감도위56.8%,특이도위98.3%,구유일정준학성。결론 RDW치적변화대판단폐암환자전이정황유일정적응용개치。(중화검험의학잡지,2014,37:444-446)
Objective To investigate the clinical value of whole blood red cell distribution width ( RDW) in discriminating lung cancer metastasis.Methods A retrospective analysis was conducted on the patients who were initially diagnosed as primary lung cancer.A total of 525 patients were included for analysis between January 2012 and July 2013,stratified by different stages and metastasis scenarios.RDW data was investigated.Kruskal-Wallis H tests were performed to know the difference of RDW without and within groups.Spearman correlation test was done subsequently to further analyze the correlationship among RDW and clinical parameters.Results RDW was14.5 ( 13.0-15.4 )%in patients with metastasis , which was significantly higher than those without metastasis [12.7 (12.3-13.0)%].Further analysis indicated a similar ascending trend in cases that already had distant or multiple organ invasion.For example,RDW was 14.6 (12.9-15.4) %in patients of stage ⅢtoⅣ,while was 12.6 (12.2-13.1) %in patients of stageⅠtoⅡ.RDW was correlated to lung cancer metastasis and stage advancement.Areas Under Curve ( AUCs) of ROC for lung cancer metastasis and distant metastasis were 0.823 ( 95% CI:0.787-0.859 ) and 0.710 (95%CI:0.655-0.765) respectively,indicating a promising accuracy.The Cut-off value for discriminating lung cancer with/without metastasis was 14.25% with sensitivity being 56.8% and specificity being 98.3%.Conclusion RDW may be a novel biomarker for auxiliary diagnosis of lung cancer metastasis and could be useful to understand state of illness.