CAJ | 학술논문

探讨糖尿病肾病（DN）患者血清1，25二羟维生素D3[1，25（OH）2D3]与氧化应激的关系。 DN组血清1，25（OH）2D3水平明显低于糖尿病（DM）组和正常对照组。在 DN 患者，1，25（OH）2D3与晚期氧化蛋白产物（AOPP，r＝-0.646，P＜0.01）、活性氧簇（ROS，r＝-0.703，P＜0.01）呈负相关，与超氧化物歧化酶（SOD，r＝0.962，P＜0.01）呈正相关。多元逐步线性回归分析显示，1，25（OH）2D3、LDL-C、BMI、血肌酐和年龄影响DN患者体内氧化应激系统。随着慢性肾脏病的进展，血清AOPP、ROS水平显著升高，SOD水平显著下降，血清1，25（OH）2D3水平亦明显降低。
탐토당뇨병신병（DN）환자혈청1，25이간유생소D3[1，25（OH）2D3]여양화응격적관계。 DN조혈청1，25（OH）2D3수평명현저우당뇨병（DM）조화정상대조조。재 DN 환자，1，25（OH）2D3여만기양화단백산물（AOPP，r＝-0.646，P＜0.01）、활성양족（ROS，r＝-0.703，P＜0.01）정부상관，여초양화물기화매（SOD，r＝0.962，P＜0.01）정정상관。다원축보선성회귀분석현시，1，25（OH）2D3、LDL-C、BMI、혈기항화년령영향DN환자체내양화응격계통。수착만성신장병적진전，혈청AOPP、ROS수평현저승고，SOD수평현저하강，혈청1，25（OH）2D3수평역명현강저。
To explore the relationship between serum 1,25(OH)2D3 and oxidative stress in patients with diabetic nephropathy (DN).The serum levels of 1,25(OH)2D3 in DN patients were significantly lower than those in DM and healthy controls.And the 1,25(OH)2D3 level was negatively correlated with advanced oxidation protein products ( AOPP ) , reactive oxygen species ( ROS ) and positively correlated with superoxide dismutase (SOD) in DN patients.1,25(OH)2D3, low density lipoprotein-cholesterol (LDL-C), body mass index ( BMI) , serum creatinine and age were associated with the level of oxidative stress in DN patients.With the progression of CKD , the serum levels of AOPP and ROS increased significantly while those of SOD and 1,25(OH)2D3 decreased markedly.