CAJ | 학술논문

目的：观察当归、红花两药味不同配比对血虚小鼠的补血作用差异，优选当归-红花配伍补血作用的最佳配比。方法采用乙酰苯肼与环磷酰胺联合造模法复制小鼠血虚模型。基于多指标综合指数法，首先以《中医方剂大辞典》数据库中出现频次最高的当归-红花1：1配比为代表，优选当归、红花配伍补血作用的最佳浓度；然后采用优选的最佳浓度来观察当归、红花不同配比的补血作用变化规律。结果在3个不同浓度(分别为当归、红花临床等效量的1、3、5倍)下，当归-红花剂量为临床等效量时的总补血效应最好；在当归、红花的9个不同配比(1：0、4：1、2：1、3：2、1：1、2：3、1：2、1：4和0：1)中，以当归-红花1：1的总补血效应最好。结论与中医方剂中使用当归、红花1：1频次最高的用药规律相一致，为现代临床更有效应用当归与红花提供了科学依据。
목적：관찰당귀、홍화량약미불동배비대혈허소서적보혈작용차이，우선당귀-홍화배오보혈작용적최가배비。방법채용을선분정여배린선알연합조모법복제소서혈허모형。기우다지표종합지수법，수선이《중의방제대사전》수거고중출현빈차최고적당귀-홍화1：1배비위대표，우선당귀、홍화배오보혈작용적최가농도；연후채용우선적최가농도래관찰당귀、홍화불동배비적보혈작용변화규률。결과재3개불동농도(분별위당귀、홍화림상등효량적1、3、5배)하，당귀-홍화제량위림상등효량시적총보혈효응최호；재당귀、홍화적9개불동배비(1：0、4：1、2：1、3：2、1：1、2：3、1：2、1：4화0：1)중，이당귀-홍화1：1적총보혈효응최호。결론여중의방제중사용당귀、홍화1：1빈차최고적용약규률상일치，위현대림상경유효응용당귀여홍화제공료과학의거。
Aim To observe the differences of tonify-ing blood effect for the combination of Danggui and Honghua ( GH) with different proportions on blood de-ficiency mice, and choose the proportion of GH which has the optimal tonifying blood effect. Methods The blood deficient mice model was induced by injection of phenylhydrazine and cyclophosphamide. On the basis of multi-attribute comprehensive index method, the op-timal dose was determined through three doses of GH 1: 1 , which was the highest frequency proportion of GH used in the “Dictionary of Chinese Medicine Prescrip-tions”. According to the optimal dose, the change reg-ulation of tonifying blood effect of GH with different proportions was observed. Results Among three do- <br> ses (1, 3 and 5 times of clinical dose), the tonifying blood effect of GH was best when the dosing concentra-tion of GH was clinical dose. Among nine proportions (1 : 0, 4 : 1, 2 : 1, 3 : 2, 1 : 1, 2 : 3, 1 : 2, 1 : 4 and 0 : 1), GH 1 : 1 had the best effect. Conclusion The results are consistent with regulations of medi-cine usage that GH 1 : 1 has the highest frequency used in Herbal Formulae, which could provide scientif-ic basis for more effective application of Danggui and Honghua in modern clinic medicine.